The LZTS2 Polyclonal Antibody (CAB14598) is a valuable tool for research involving LZTS2, a tumor suppressor gene implicated in cell cycle regulation and tumor development. This antibody, generated in rabbits, is highly specific for human samples and has been validated for use in various applications, including Western blot and immunohistochemistry.LZTS2, also known as leucine zipper putative tumor suppressor 2, is recognized for its role in promoting cell cycle arrest and apoptosis, thereby suppressing tumor growth and metastasis.
Its importance in cancer biology makes it a promising target for therapeutic interventions aimed at inhibiting tumor progression.The LZTS2 Polyclonal Antibody binds specifically to the LZTS2 protein, allowing for precise detection and analysis in different cell types and tissue samples. It is an essential tool for researchers studying the mechanisms underlying tumor development and progression, as well as for those investigating potential treatment strategies targeting LZTS2 function.
Product Name:
LZTS2 Rabbit Polyclonal Antibody
SKU:
CAB14598
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 470-669 of human LZTS2 (NP_115805.1).
The protein encoded by this gene belongs to the leucine zipper tumor suppressor family of proteins, which function in transcription regulation and cell cycle control. This family member can repress beta-catenin-mediated transcriptional activation and is a negative regulator of the Wnt signaling pathway. It negatively regulates microtubule severing at centrosomes, and is necessary for central spindle formation and cytokinesis completion. It is implicated in cancer, where it may inhibit cell proliferation and decrease susceptibility to tumor development. Alternative splicing of this gene results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
84445
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using LZTS2 Rabbit pAb (CAB14598) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
