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Anti-LEFTY1/2 Antibody (CAB2387)

SKU:
CAB2387
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
LEFTB
LEFTYB
Research Area:
Autophagy
€139 - €419
Frequently bought together:

Description

Anti-LEFTY1/2 Antibody (CAB2387)

The Anti-LEFTY1/2 Antibody (CAB2387) is a highly specific tool for researchers studying the LEFTY1 and LEFTY2 proteins, known for their roles in embryonic development and cell differentiation. This polyclonal antibody, produced in rabbits, is optimized for use in Western blot applications and is compatible with human samples. By binding to LEFTY1 and LEFTY2, this antibody enables precise detection and analysis of these important proteins in a variety of cell types.LEFTY1 and LEFTY2 are key factors in the regulation of embryonic development, particularly in the formation of the left-right axis in vertebrates.

Understanding the functions of LEFTY1 and LEFTY2 is crucial for unraveling the complexities of developmental biology and may provide insights into disorders related to organ positioning and development. The Anti-LEFTY1/2 Antibody (CAB2387) is a valuable tool for researchers investigating these processes and their implications for human health.

Product Name:LEFTY1/2 Rabbit mAb
Product Code:CAB2387
Size:20uL, 50uL, 100uL
Synonyms:LEFTB, LEFTYB
Applications:WB, IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human LEFTY1/2
Applications:WB, IHC
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HT-29, BxPC-3, Mouse brain, Rat brain
Immunogen:A synthesized peptide derived from human LEFTY1/2
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:10637/7044
Uniprot:O75610/O00292
Calculated MW:34.44kDa
Observed MW:41KDa
UniProt Protein Function:LEFTY1: Required for left-right axis determination as a regulator of LEFTY2 and NODAL. Belongs to the TGF-beta family.
UniProt Protein Details:

Protein type:Cytokine; Ligand, receptor tyrosine kinase; Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 1q42.1

Cellular Component: extracellular space

Molecular Function:cytokine activity; transforming growth factor beta receptor binding

Biological Process: cell development; determination of left/right symmetry; heart morphogenesis; negative regulation of transcription from RNA polymerase II promoter; regulation of apoptosis; regulation of MAPKKK cascade; transforming growth factor beta receptor signaling pathway

NCBI Summary:This gene encodes a member of the TGF-beta family of proteins. A similar secreted protein in mouse plays a role in left-right asymmetry determination of organ systems during development. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene. [provided by RefSeq, Jul 2008]
UniProt Code:O75610
NCBI GenInfo Identifier:13124321
NCBI Gene ID:10637
NCBI Accession:O75610.1
UniProt Secondary Accession:O75610,Q53H67, Q5TE94, B2R7U0,
UniProt Related Accession:O75610
Molecular Weight:40,880 Da
NCBI Full Name:Left-right determination factor 1
NCBI Synonym Full Names:left-right determination factor 1
NCBI Official Symbol:LEFTY1  
NCBI Official Synonym Symbols:LEFTB; LEFTYB  
NCBI Protein Information:left-right determination factor 1
UniProt Protein Name:Left-right determination factor 1
UniProt Synonym Protein Names:Left-right determination factor B; Protein lefty-1; Protein lefty-B
Protein Family:Left-right determination factor
UniProt Gene Name:LEFTY1  
UniProt Entry Name:LFTY1_HUMAN

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