The LAMA2 Antibody (PAC023341) is a valuable tool for research involving Laminin subunit alpha-2 (LAMA2), a protein that plays a critical role in cell adhesion and muscle development. This polyclonal antibody is produced in rabbits and is highly reactive with human samples, making it ideal for Western blot applications. By specifically binding to the LAMA2 protein, this antibody facilitates the detection and analysis of LAMA2 in a variety of cell types.LAMA2 is an essential component of the extracellular matrix in muscle tissue and is particularly important for the proper function of skeletal muscle. Mutations in the LAMA2 gene have been associated with congenital muscular dystrophy, making it a target of interest in research related to muscle development and disease.
By studying the expression and regulation of LAMA2, researchers can gain insights into the underlying mechanisms of muscular dystrophy and potentially identify therapeutic targets for this condition.Overall, the LAMA2 Antibody (PAC023341) is a valuable research tool for studies in muscle biology, developmental biology, and muscular dystrophy, offering researchers the ability to accurately detect and analyze LAMA2 protein expression in a variety of experimental settings.
Synthesized peptide derived from internal of human LAMA2.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Immunohistochemistry analysis of paraffin-embedded human placenta tissue using LAMA2 antibody.
Immunofluorescence analysis of NIH/3T3 cells, using LAMA2 antibody.
Background:
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
Synonyms:
LAMM; laminin M; laminin alpha-2; merosin heavy chain;
UniProt Protein Function:
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
UniProt Protein Details:
NCBI Summary:
Laminin, an extracellular protein, is a major component of the basement membrane. It is thought to mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. It is composed of three subunits, alpha, beta, and gamma, which are bound to each other by disulfide bonds into a cross-shaped molecule. This gene encodes the alpha 2 chain, which constitutes one of the subunits of laminin 2 (merosin) and laminin 4 (s-merosin). Mutations in this gene have been identified as the cause of congenital merosin-deficient muscular dystrophy. Two transcript variants encoding different proteins have been found for this gene. [provided by RefSeq, Jul 2008]
