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KRT5 Monoclonal Antibody [PAT12C4AT] (CPAB0639)

SKU:
CPAB0639
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Universal
Host Species:
Mouse
Isotype:
IgG1
Clone:
PAT12C4AT
Applications:
WB
ELISA
FC
€149
Frequently bought together:

Description

system_update_alt Datasheet

KRT5 Monoclonal Antibody [PAT12C4AT] (CPAB0639)

The KRT5 Polyclonal Antibody (CPAB0639) is a valuable tool for researchers studying keratin 5, a key protein in the cytoskeleton of epithelial cells. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the KRT5 protein, it allows for the detection and analysis of this important cytoskeletal component in various cell types.Keratin 5 is essential for maintaining the structural integrity of epithelial tissues and plays a crucial role in cell migration, proliferation, and differentiation.

Dysregulation of KRT5 expression has been associated with various skin disorders, including blistering diseases and skin cancers. By studying the function and regulation of KRT5, researchers can gain insights into the pathogenesis of these conditions and potentially identify new therapeutic targets.Overall, the KRT5 Polyclonal Antibody is a reliable tool for investigating the role of keratin 5 in cellular processes and disease mechanisms, making it a valuable asset for studies in dermatology, oncology, and regenerative medicine.

Product Name:KRT5 Antibody
Product Sku:CPAB0639
Size:5μg
Host Species:Mouse
Immunogen:Anti-human KRT5 mAb, is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human KRT5 protein 1-59 amino acids purified from Ecoli.
Clone:PAT12C4AT.
Reactivity:Other bodies
Applications:Western Blot, ELISA, Flow Cytometry
Purification Method:KRT5 antibody was purified from mouse ascitic fluids by protein-A affinity chromatography.
Isotype:IgG1
Background:Cytokeratin 5 (KRT5) belongs to the keratin gene family. The type II cytokeratins are comprised of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed throughout differentiation of simple and stratified epithelial tissues. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. The KRT5 type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. Mutations in these genes are linked with a complex of diseases termed epidermolysis bullosa simplex.
Synonyms:Keratin 5, KRT5, EBS2, Epidermolysis Bullosa Simplex 2 Dowling-Meara/Kobner/Weber-Cockayne Types, Keratin 5 (Epidermolysis Bullosa Simplex,Dowling-Meara/Kobner/Weber-Cockayne Types), 58 KDa Cytokeratin, Type-II Keratin Kb5, CK-5, K5, DDD1, CK5, DDD, KRT5A, cytokeratin-5, Keratin, Type II Cytoskeletal 5, Cytokeratin-5, Keratin-5.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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