The KIF1BP Polyclonal Antibody (PACO58304) is a valuable tool for researchers studying KIF1BP, a protein involved in intracellular transport and microtubule dynamics. This antibody, produced in rabbits, exhibits high specificity and sensitivity for human samples, and has been validated for use in Western blot applications. By targeting the KIF1BP protein, this antibody enables precise detection and analysis in various cell types, making it ideal for investigations in cell biology and neurology.KIF1BP, also known as kinesin-binding protein, plays a crucial role in regulating the transport of vesicles along microtubules, facilitating essential cellular processes such as neurotransmitter release and organelle movement.
Its involvement in intracellular trafficking pathways makes it a promising target for research into neurological disorders, neurodegenerative diseases, and cellular transport mechanisms. Understanding the functions of KIF1BP is key to unraveling its contributions to cellular physiology and pathology, paving the way for potential therapeutic interventions targeting this protein.
IHC image of PACO58304 diluted at 1:400 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Immunofluorescence staining of Hela cells with PACO58304 at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
IHC image of PACO58304 diluted at 1:400 and staining in paraffin-embedded human skeletal muscle tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Background:
Required for organization of axonal microtubules, and axonal outgrowth and maintenance during peripheral and central nervous system development.
Synonyms:
KIF1-binding protein, KIF1BP, KBP KIAA1279
UniProt Protein Function:
UniProt Protein Details:
NCBI Summary:
This gene encodes a kinesin family member 1 binding protein that is characterized by two tetratrico peptide repeats. The encoded protein localizes to the mitochondria and may be involved in regulating transport of the mitochondria. Mutations in this gene are associated with Goldberg-Shprintzen megacolon syndrome. [provided by RefSeq, Mar 2010]
