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[KD Validated] COX7A2L Polyclonal Antibody (CAB23681)

SKU:
CAB23681
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
€139 - €529
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Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:[KD Validated] COX7A2L Polyclonal Antibody
SKU:CAB23681
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human
Immunogen:Recombinant protein of human COX7A2L.
Sequence:MYYK FSGF TQKL AGAW ASEA YSPQ GLKP VVST EAPP IIFA TPTK LTSD STVY DYAG KNKV PELQ KFFQ KADG VPVY LKRG LPDQ MLYR TTMA LTVG GTIY CLIA LYMA SQPK NK
Tested Applications:WB ELISA
Recommended Dilution:WB,1:1000 - 1:5000
Synonyms:EB1; SCAF1; SCAFI; SIG81; COX7AR; COX7RP; [KD Validated] COX7A2L
Positive Sample:HeLa
Conjugate:Unconjugated
Cellular Localization:Mitochondrion inner membrane.
Calculated MW:13kDa
Observed MW:14kDa

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein similar to polypeptides 1 and 2 of subunit VIIa in the C-terminal region, and also highly similar to the mouse Sig81 protein sequence. This gene is expressed in all tissues, and upregulated in a breast cancer cell line after estrogen treatment. It is possible that this gene represents a regulatory subunit of COX and mediates the higher level of energy production in target cells by estrogen. Several transcript variants, some protein-coding and others non-protein coding, have been found for this gene.

Purification Method:Affinity purification
Gene ID:9167
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Product ImageWestern blot analysis of lysates from wild type(WT) and COX7A2L knockdown (KD) HeLa cells, using [KD Validated] COX7A2L Rabbit pAb (CAB23681) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.

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