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KCNB1 Antibody (PACO19583)

SKU:
PACO19583
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
  • KCNB1 Antibody PACO19583
  • KCNB1 Antibody PACO19583
€339
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Description

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KCNB1 Antibody (PACO19583)

The KCNB1 Monoclonal Antibody (PACO19583) is a key tool for researchers studying the KCNB1 protein, a voltage-gated potassium channel crucial for regulating neuronal excitability. This monoclonal antibody, produced using state-of-the-art techniques, is highly specific to human KCNB1 and has been validated for use in various applications, including Western blot and immunohistochemistry.KCNB1 is essential for maintaining proper electrical activity in neurons and plays a critical role in neuronal function and communication. Dysregulation of KCNB1 has been linked to neurological disorders such as epilepsy and neurodegenerative diseases, making it an important target for research in the field of neuroscience.

By using the KCNB1 Monoclonal Antibody, researchers can accurately detect and analyze KCNB1 expression in different cell types and tissues, providing valuable insights into its function and potential therapeutic applications. This antibody is a valuable tool for advancing our understanding of neuronal excitability and developing targeted treatments for neurological conditions.

Antibody Name:KCNB1 Antibody (PACO19583)
Antibody SKU:PACO19583
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, IHC
Recommended Dilutions:ELISA:1:1000-1:2000, IHC:1:25-1:100
Species Reactivity:Human, Mouse
Immunogen:Synthetic peptide of human KCNB1
Form:Liquid
Storage Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:Antigen affinity purification
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageThe image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO19583(KCNB1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
Product ImageThe image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19583(KCNB1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel and its activity is modulated by some other family members.
Synonyms:potassium voltage-gated channel, Shab-related subfamily, member 1
UniProt Protein Function:Kv2.1: a potassium voltage-gated channel protein of subfamily B. Mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in response to the voltage difference across the membrane, letting K ions pass in accordance with their electrochemical gradient.Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass; Channel, cation; Channel, ligand-gatedChromosomal Location of Human Ortholog: 20q13.2Cellular Component: postsynaptic membrane; voltage-gated potassium channel complex; dendrite; plasma membrane; integral to membraneMolecular Function: protein binding; outward rectifier potassium channel activity; delayed rectifier potassium channel activity; protein N-terminus bindingBiological Process: synaptic transmission; energy reserve metabolic process; regulation of insulin secretion; protein homooligomerizationDisease: Epileptic Encephalopathy, Early Infantile, 26
UniProt Protein Details:
NCBI Summary:Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel and its activity is modulated by some other family members. [provided by RefSeq, Jul 2008]
UniProt Code:Q14721
NCBI GenInfo Identifier:24418854
NCBI Gene ID:3745
NCBI Accession:Q14721.2
UniProt Secondary Accession:Q14721,Q14193
UniProt Related Accession:Q14721
Molecular Weight:95,878 Da
NCBI Full Name:Potassium voltage-gated channel subfamily B member 1
NCBI Synonym Full Names:potassium voltage-gated channel, Shab-related subfamily, member 1
NCBI Official Symbol:KCNB1  
NCBI Official Synonym Symbols:DRK1; KV2.1; EIEE26; h-DRK1  
NCBI Protein Information:potassium voltage-gated channel subfamily B member 1; h-DRK1 K(+) channel; potassium channel protein DRK1; delayed rectifier potassium channel 1; delayed rectifier potassium channel Kv2.1; voltage-gated potassium channel subunit Kv2.1
UniProt Protein Name:Potassium voltage-gated channel subfamily B member 1
UniProt Synonym Protein Names:Delayed rectifier potassium channel 1; DRK1; h-DRK1; Voltage-gated potassium channel subunit Kv2.1
Protein Family:Potassium voltage-gated channel subfamily
UniProt Gene Name:KCNB1  
UniProt Entry Name:KCNB1_HUMAN
Antibodies
Phospho-KCNB1 (S805) Antibody (PACO05959)
Phospho-KCNB1 (S567) Antibody (PACO05960)
KCNB1 Antibody (PACO05961)
KCNB1 Antibody (PACO05962)
Secondary Antibody
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)
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