The KAT2B Polyclonal Antibody (CAB0066) is a valuable tool for researchers studying KAT2B, a protein involved in epigenetic regulation and gene transcription. Raised in rabbits, this antibody is highly specific and reactive with human samples, making it ideal for use in Western blot applications. By binding to the KAT2B protein, researchers can detect and analyze its expression in various cell types, providing insights into its function in processes such as chromatin remodeling and cellular differentiation.KAT2B, also known as GCN5, is a histone acetyltransferase that plays a crucial role in regulating gene expression through histone acetylation.
Dysregulation of KAT2B has been associated with various diseases, including cancer and developmental disorders. By studying the role of KAT2B in these contexts, researchers can gain a better understanding of its function and potential as a therapeutic target.Overall, the KAT2B Polyclonal Antibody (CAB0066) is a valuable tool for researchers investigating the role of KAT2B in epigenetic regulation and gene expression. Its high specificity and reactivity make it a reliable choice for studies in molecular biology, cancer research, and developmental biology.
Product Name:
KAT2B Rabbit Polyclonal Antibody
SKU:
CAB0066
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-86 of human KAT2B/PCAF (NP_003875.3).
CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation, including c-jun and the adenoviral oncoprotein E1A. The protein encoded by this gene associates with p300/CBP. It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. It has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that this protein plays a direct role in transcriptional regulation.
Purification Method:
Affinity purification
Gene ID:
8850
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates, using KAT2B/PCAF Rabbit pAb (CAB0066) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
