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INSR/IGF1R Monoclonal Antibody (CAB21984)

SKU:
CAB21984
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
€139 - €529
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:INSR/IGF1R Monoclonal Antibody
SKU:CAB21984
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:Recombinant protein of human INSR/IGF1R.
Tested Applications:WB ELISA
Recommended Dilution:WB,1:1000 - 1:5000
Synonyms:HHF5; CD220; IGFR; CD221; IGFIR; JTK13; INSR/IGF1R
Positive Sample:3T3L1,MCF7,C6
Conjugate:Unconjugated
Cellular Localization:axon, caveola, dendrite membrane, external side of plasma membrane, extracellular exosome, late endosome, lysosome, plasma membrane
Calculated MW:156kDa
Observed MW:97kDa

This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants.

Purification Method:Affinity purification
Gene ID:3643/ 3480
Clone Number:ARC54074
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using INSR/IGF1R Rabbit mAb (CAB21984) at1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.

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