The IMPDH1 Polyclonal Antibody (CAB16899) is a valuable tool for researchers studying IMPDH1, an enzyme involved in nucleotide metabolism and cell proliferation. This rabbit polyclonal antibody is highly specific and reactive with human samples, making it ideal for use in Western blot applications. By binding to the IMPDH1 protein, this antibody allows for the detection and analysis of IMPDH1 levels in various cell types.IMPDH1 is a key enzyme in the de novo synthesis of guanine nucleotides, making it essential for DNA and RNA production in rapidly dividing cells.
Dysregulation of IMPDH1 has been linked to various diseases, including cancer and autoimmune disorders. By studying IMPDH1 expression and activity, researchers can gain insights into the underlying mechanisms of these diseases and potentially identify new therapeutic targets.Overall, the IMPDH1 Polyclonal Antibody is a valuable tool for researchers interested in exploring the role of nucleotide metabolism in health and disease. Its specificity and sensitivity make it a reliable choice for studies in molecular biology, biochemistry, and cancer research.
Product Name:
IMPDH1 Rabbit Polyclonal Antibody
SKU:
CAB16899
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 434-563 of human IMPDH1 (NP_899066.1).
The protein encoded by this gene acts as a homotetramer to regulate cell growth. The encoded protein is an enzyme that catalyzes the synthesis of xanthine monophosphate (XMP) from inosine-5'-monophosphate (IMP). This is the rate-limiting step in the de novo synthesis of guanine nucleotides. Defects in this gene are a cause of retinitis pigmentosa type 10 (RP10). Several transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
3614
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using IMPDH1 Rabbit pAb (CAB16899) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
