IL10 Rabbit Polyclonal Antibody (CAB17501)
- SKU:
- CAB17501
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | IL10 Rabbit Polyclonal Antibody |
SKU: | CAB17501 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human IL10 (NP_000563.1). |
Sequence: | RVKT FFQM KDQL DNLL LKES LLED FKGY LGCQ ALSE MIQF YLEE VMPQ AENQ DPDI KAHV NSLG ENLK TLRL RLRR CHRF LPCE NKSK AVEQ VKNA FNKL Q |
Tested Applications: | IF/ICC ELISA |
Recommended Dilution: | IF/ICC,1:50 - 1:200 |
Synonyms: | CSIF; TGIF; GVHDS; IL-10; IL10A; IL10 |
Conjugate: | Unconjugated |
Cellular Localization: | Secreted. |
Calculated MW: | 21kDa |
Observed MW: | Refer to figures |
The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.
Purification Method: | Affinity purification |
Gene ID: | 3586 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |