The IGF1R Rabbit Polyclonal Antibody (CAB16884) is a valuable tool for research involving the insulin-like growth factor 1 receptor (IGF1R), a key player in cell growth, differentiation, and survival. This antibody, raised in rabbits, is highly specific for human samples and is validated for use in Western blot applications. It recognizes the IGF1R protein, allowing for the detection and analysis of this receptor in various cell types.IGF1R is a transmembrane receptor tyrosine kinase that plays a crucial role in promoting cell proliferation and survival. Dysregulation of IGF1R signaling has been implicated in various diseases, including cancer, diabetes, and neurological disorders.
By studying IGF1R expression and activity, researchers can gain valuable insights into the mechanisms underlying these diseases and potentially identify new therapeutic targets.The IGF1R Rabbit Polyclonal Antibody is a valuable tool for investigating the role of IGF1R in various physiological and pathological processes. Its high specificity and sensitivity make it well-suited for immunology and cancer research studies. By understanding the function of IGF1R, researchers can potentially develop targeted therapies that modulate IGF1R signaling for the treatment of a wide range of diseases.
Product Name:
IGF1R Rabbit Polyclonal Antibody
SKU:
CAB16884
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 741-935 of human IGF1R (NP_000866.1).
Cell membrane, Single-pass type I membrane protein.
Calculated MW:
155kDa
Observed MW:
90kDa
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
3480
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using IGF1R Rabbit pAb (CAB16884) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
