Human YKL-40/CHI3L1 Polyclonal Antibody (CAB22029)
The Human YKL-40/CHI3L1 Polyclonal Antibody is a valuable tool for researchers studying the YKL-40 protein, also known as chitinase-3-like protein 1, which is implicated in various inflammatory and disease processes. This antibody, produced in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot applications.YKL-40 is a glycoprotein that has been linked to various conditions, including cancer, inflammation, and tissue remodeling. The antibody binds specifically to the YKL-40 protein, allowing for its detection and analysis in a variety of cell types.
This makes it an ideal choice for studies in immunology, cancer biology, and other areas where YKL-40 is of interest.The role of YKL-40 in disease processes makes it a promising target for therapeutic intervention, particularly in cancer and inflammatory disorders. By understanding the function and regulation of YKL-40, researchers may uncover new opportunities for the development of treatments that target this protein and its associated pathways. Heightened understanding of YKL-40 may also lead to improved diagnostic tools for diseases where it plays a role.
Product Name:
Human YKL-40/CHI3L1 Polyclonal Antibody
SKU:
CAB22029
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 22-383 of human YKL-40/CHI3L1 (NP_001267.2).
cytoplasm, endoplasmic reticulum, extracellular exosome, extracellular region, extracellular space, perinuclear region of cytoplasm
Calculated MW:
43kDa
Observed MW:
43kDa
Chitinases catalyze the hydrolysis of chitin, which is an abundant glycopolymer found in insect exoskeletons and fungal cell walls. The glycoside hydrolase 18 family of chitinases includes eight human family members. This gene encodes a glycoprotein member of the glycosyl hydrolase 18 family. The protein lacks chitinase activity and is secreted by activated macrophages, chondrocytes, neutrophils and synovial cells. The protein is thought to play a role in the process of inflammation and tissue remodeling.
Purification Method:
Affinity purification
Gene ID:
1116
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using Human YKL-40/CHI3L1 antibody (CAB22029) at 1:400 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
