Human TSC22D3 Recombinant Protein (RPPB5026)
- SKU:
- RPPB5026
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q99576
Description
| Product Name: | Human TSC22D3 Recombinant Protein |
| Product Code: | RPPB5026 |
| Size: | 10µg |
| Species: | Human |
| Target: | TSC22D3 |
| Synonyms: | TSC22 domain family protein 3, DSIP-immunoreactive peptide, Protein DIP, hDIP, Delta sleep-inducing peptide immunoreactor, Glucocorticoid-induced leucine zipper protein, GILZ, TSC-22-like protein, TSC-22-related protein, TSC-22R, TSC22D3, DSIPI, DIP. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | TSC22D3 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMNTEMYQ TPMEVAVYQL HNFSISFFSS LLGGDVVSVK LDNSASGASV VAIDNKIEQA MDLVKNHLMY AVREEVEILK EQIRELVEKN SQLERENTLL KTLASPEQLE KFQSCLSPEE PAPESPQVPE APGGSAV |
TSC22 domain family protein 3 (TSC22D3) protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity which initiates the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, TSC22D3 has a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, TSC22D3 hinders anti-CD3-induced NFKB1 nuclear translocation. In vitro, TSC22D3 curbs AP1 and NFKB1 DNA-binding activities.
TSC22D3 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 157 amino acids (1-134 a.a) and having a molecular mass of 17.2kDa.TSC22D3 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | GILZ: Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities. Belongs to the TSC-22/Dip/Bun family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: Xq22.3 Cellular Component: cytosol Biological Process: regulation of transcription, DNA-dependent |
| NCBI Summary: | This gene encodes the anti-inflammatory protein glucocorticoid (GC)-induced leucine zipper. Expression of this gene stimulated by glucocorticoids and interleukin 10 and it appears to play a key role in the anti-inflammatory and immunosuppressive effects of this steroid. This protein has also been shown to inhibit pro-inflammatory molecules including nuclear factor κB. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016] |
| UniProt Code: | Q99576 |
| NCBI GenInfo Identifier: | 14195584 |
| NCBI Gene ID: | 1831 |
| NCBI Accession: | Q99576.2 |
| UniProt Secondary Accession: | Q99576,Q5H9S3, Q5JRI9, Q6FIH6, Q8NAI1, Q8WVB9, Q9UBN5 Q9UG13, |
| UniProt Related Accession: | Q99576 |
| Molecular Weight: | 13,286 Da |
| NCBI Full Name: | TSC22 domain family protein 3 |
| NCBI Synonym Full Names: | TSC22 domain family member 3 |
| NCBI Official Symbol: | TSC22D3�� |
| NCBI Official Synonym Symbols: | DIP; GILZ; DSIPI; TSC-22R�� |
| NCBI Protein Information: | TSC22 domain family protein 3 |
| UniProt Protein Name: | TSC22 domain family protein 3 |
| UniProt Synonym Protein Names: | DSIP-immunoreactive peptide; Protein DIP; hDIP; Delta sleep-inducing peptide immunoreactor; Glucocorticoid-induced leucine zipper protein; GILZ; TSC-22-like protein; TSC-22-related protein; TSC-22R |
| Protein Family: | TSC22 domain family protein |
| UniProt Gene Name: | TSC22D3�� |
| UniProt Entry Name: | T22D3_HUMAN |
