Human STX2 Recombinant Protein (RPPB4866)
- SKU:
- RPPB4866
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P32856
Description
| Product Name: | Human STX2 Recombinant Protein |
| Product Code: | RPPB4866 |
| Size: | 10µg |
| Species: | Human |
| Target: | STX2 |
| Synonyms: | Syntaxin 2, epimorphin, EPM, EPIM, STX2A, STX2B, STX2C. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The STX2 solution (0.25mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 100mM NaCl, 1mM DTT and 50% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSHMMRDRL PDLTACRKND DGDTVVVVEK DHFMDDFFHQ VEEIRNSIDK ITQYVEEVKK NHSIILSAPN PEGKIKEELE DLNKEIKKTA NKIRAKLKAI EQSFDQDESG NRTSVDLRIR RTQHSVLSRK FVEAMAEYNE AQTLFRERSK GRIQRQLEIT GRTTTDDELE EMLESGKPSI FTSDIISDSQ ITRQALNEIE SRHKDIMKLE TSIRELHEMF MDMAMFVETQ GEMINNIERN VMNATDYVEH AKEETKKAIK YQSKARRKK |
Syntaxin-2 (STX2) is a member of the syntaxin/epimorphin family of proteins. Syntaxin family members are cellular receptors for transport vesicles which participate in exocytosis in neutrophils. STX2 regulates epithelial-mesenchymal interactions and epithelial cell morphogenesis and activation. STX2 is a t-SNARE which localizes to the apical plasma membrane and intracellular vesicular structures. In addition, STX2, along with SNAP-23, is essential for regulated surfactant secretion.
STX2 Human Recombinant produced in E. coli is a single polypeptide chain containing 289 amino acids (1-264) and having a molecular mass of 33.6 kDa.STX2 is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | STX2: Essential for epithelial morphogenesis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm. Belongs to the syntaxin family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Vesicle; Membrane protein, integral Chromosomal Location of Human Ortholog: 12q24.33 Cellular Component: basolateral plasma membrane; extracellular space; integral to membrane; intracellular membrane-bound organelle; lamellipodium; plasma membrane; SNARE complex; synaptic vesicle Molecular Function:calcium-dependent protein binding; protein binding; protein dimerization activity; SNAP receptor activity; SNARE binding Biological Process: acrosome reaction; ectoderm development; intracellular protein transport; organ morphogenesis; protein oligomerization; regulation of blood coagulation; response to hydroperoxide; signal transduction; synaptic vesicle fusion to presynaptic membrane; vesicle docking |
| NCBI Summary: | The product of this gene belongs to the syntaxin/epimorphin family of proteins. The syntaxins are a large protein family implicated in the targeting and fusion of intracellular transport vesicles. The product of this gene regulates epithelial-mesenchymal interactions and epithelial cell morphogenesis and activation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P32856 |
| NCBI GenInfo Identifier: | 292495060 |
| NCBI Gene ID: | 2054 |
| NCBI Accession: | P32856.3 |
| UniProt Secondary Accession: | P32856,Q86VW8, |
| UniProt Related Accession: | P32856 |
| Molecular Weight: | 32,425 Da |
| NCBI Full Name: | Syntaxin-2 |
| NCBI Synonym Full Names: | syntaxin 2 |
| NCBI Official Symbol: | STX2�� |
| NCBI Official Synonym Symbols: | EPM; EPIM; STX2A; STX2B; STX2C�� |
| NCBI Protein Information: | syntaxin-2 |
| UniProt Protein Name: | Syntaxin-2 |
| UniProt Synonym Protein Names: | Epimorphin |
| Protein Family: | Syntaxin |
| UniProt Gene Name: | STX2�� |
| UniProt Entry Name: | STX2_HUMAN |
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