Human RRAS2 Recombinant Protein (RPPB4527)
- SKU:
- RPPB4527
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P62070
Description
| Product Name: | Human RRAS2 Recombinant Protein |
| Product Code: | RPPB4527 |
| Size: | 50µg |
| Species: | Human |
| Target: | RRAS2 |
| Synonyms: | Ras-related protein R-Ras2, Ras-like protein TC21, Teratocarcinoma oncogene, RRAS2, TC21. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The RRAS2 solution contains 20mM Tris-HCl buffer (pH8.0), 1mM DTT, 10% glycerol and 2mM EDTA. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MAAAGWRDGS GQEKYRLVVV GGGGVGKSAL TIQFIQSYFV TDYDPTIEDS YTKQCVIDDR AARLDILDTA GQEEFGAMRE QYMRTGEGFL LVFSVTDRGS FEEIYKFQRQ ILRVKDRDEF PMILIGNKAD LDHQRQVTQE EGQQLARQLK VTYMEASAKI RMNVDQAFHE LVRVIRKFQE QECPPSPEPT RKEKDKKGCH C |
RRAS2 (RAS viral (r-ras) oncogene homolog 2) is a member of the Ras like GTPase family that cycle between GTP-bound active and GDP-bound inactive states at the cytoplasmic face of the plasma membrane. RRAS2 is a plasma membrane-associated GTP-binding protein with GTPase activity. RRAS2 is implicated in the pathogenesis of human cancers. Hence, overexpression of active RRAS2 in EpH4 cells induces tumorigenicity through the phosphoinositide 3-kinase, p38 MAPK, and mTOR pathways, as these cells lose their sensitivity to the normal growth inhibitory role of TGF-beta. RRAS2 might transduce growth inhibitory signals across the cell membrane, exerting its effect via an effector shared with the Ras proteins but in an antagonistic manner.RRAS2 is ubiquitously present in all tissues examined, with the highest levels in the heart, placenta, and skeletal muscle. Moderate levels of RRAS2 are found in the lung and liver and low levels in the brain, kidney, and pancreas.RRAS2 deficiencies are linked to ovarian cancer.
RRAS2 Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 221 amino acids (1-201 a.a.) and having a molecular mass of 25.2 kDa.The RRAS2 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | RRAS2: It is a plasma membrane-associated GTP-binding protein with GTPase activity. Might transduce growth inhibitory signals across the cell membrane, exerting its effect through an effector shared with the Ras proteins but in an antagonistic fashion. Defects in RRAS2 are a cause of susceptibility to ovarian cancer (OC). The term ovarian cancer defines common malignancies originating from ovarian tissue. Although many histologic types of ovarian tumors have been described, epithelial ovarian carcinoma is the most common form. Ovarian cancers are often asymptomatic and the recognized signs and symptoms, even of late-stage disease, are vague. Consequently, most patients are diagnosed with advanced disease. Belongs to the small GTPase superfamily. Ras family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:G protein; Oncoprotein; G protein, monomeric, Ras; G protein, monomeric; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 11p15.2 Cellular Component: focal adhesion; membrane; endoplasmic reticulum; plasma membrane Molecular Function:GTPase activity; protein binding; GTP binding Biological Process: osteoblast differentiation; metabolic process; Ras protein signal transduction; positive regulation of cell migration |
| NCBI Summary: | This gene encodes a member of the R-Ras subfamily of Ras-like small GTPases. The encoded protein associates with the plasma membrane and may function as a signal transducer. This protein may play an important role in activating signal transduction pathways that control cell proliferation. Mutations in this gene are associated with the growth of certain tumors. Pseudogenes of this gene are found on chromosomes 1 and 2. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010] |
| UniProt Code: | P62070 |
| NCBI GenInfo Identifier: | 49065833 |
| NCBI Gene ID: | 22800 |
| NCBI Accession: | P62070.1 |
| UniProt Secondary Accession: | P62070,P17082, B2R9Z3, B7Z5Z2, B7Z6C4, B7Z7H6, |
| UniProt Related Accession: | P62070 |
| Molecular Weight: | 204 |
| NCBI Full Name: | Ras-related protein R-Ras2 |
| NCBI Synonym Full Names: | related RAS viral (r-ras) oncogene homolog 2 |
| NCBI Official Symbol: | RRAS2�� |
| NCBI Official Synonym Symbols: | TC21�� |
| NCBI Protein Information: | ras-related protein R-Ras2; ras-like protein TC21; teratocarcinoma oncogene |
| UniProt Protein Name: | Ras-related protein R-Ras2 |
| UniProt Synonym Protein Names: | Ras-like protein TC21; Teratocarcinoma oncogene |
| Protein Family: | Ras-related protein |
| UniProt Gene Name: | RRAS2�� |
| UniProt Entry Name: | RRAS2_HUMAN |
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