Human RPS24 Recombinant Protein (RPPB4521)

Product Name:	Human RPS24 Recombinant Protein
Product Code:	RPPB4521
Size:	10µg
Species:	Human
Target:	RPS24
Synonyms:	Ribosomal Protein S24, 40S Ribosomal Protein S24, DBA3, S24.
Source:	Escherichia Coli

Physical Appearance:	Sterile Filtered clear solution.
Formulation:	The RPS24 solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.2M NaCl, 2mM DTT and 50% glycerol.
Stability:	Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:	Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:	MGSSHHHHHH SSGLVPRGSH MGSMNDTVTI RTRKFMTNRL LQRKQMVIDV LHPGKATVPK TEIREKLAKM YKTTPDVIFV FGFRTHFGGG KTTGFGMIYD SLDYAKKNEP KHRLARHGLY EKKKTSRKQR KERKNRMKKV RGTAKANVGA GKK

RPS24 is a member of the S24E family of ribosomal proteins. RPS24 is situated in the cytoplasm. Numerous transcript variations encoding different isoforms were identified for this gene. There are multiple processed pseudogenes of this gene distributed all over the genome just like other genes encoding ribosomal proteins. Alterations in RPS24 cause Diamond-Blackfan anemia.

RPS24 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 153 amino acids (1-130) and having a molecular mass of 17.5kDa.RPS24 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:	RPS24: Required for processing of pre-rRNA and maturation of 40S ribosomal subunits. Defects in RPS24 are the cause of Diamond-Blackfan anemia type 3 (DBA3). DBA3 is a form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies. Belongs to the ribosomal protein S24e family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:RNA-binding; Ribosomal; Translation Chromosomal Location of Human Ortholog: 10q22.3 Cellular Component: cytosol; membrane; nucleoplasm; nucleus; small ribosomal subunit Molecular Function:RNA binding; translation initiation factor binding Biological Process: erythrocyte homeostasis; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); mRNA catabolic process, nonsense-mediated decay; ribosomal small subunit biogenesis and assembly; rRNA processing; SRP-dependent cotranslational protein targeting to membrane; translation; translational initiation; viral transcription Disease: Diamond-blackfan Anemia 3
NCBI Summary:	Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S24E family of ribosomal proteins. It is located in the cytoplasm. Multiple transcript variants encoding different isoforms have been found for this gene. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Mutations in this gene result in Diamond-Blackfan anemia. [provided by RefSeq, Nov 2008]
UniProt Code:	P62847
NCBI GenInfo Identifier:	51338645
NCBI Gene ID:	6229
NCBI Accession:	P62847.1
UniProt Secondary Accession:	P62847,P16632, Q5T0P7, Q5T0P8, Q7Z3D1, E7EPK6,
UniProt Related Accession:	P62847
Molecular Weight:	15kDa
NCBI Full Name:	40S ribosomal protein S24
NCBI Synonym Full Names:	ribosomal protein S24
NCBI Official Symbol:	RPS24��
NCBI Official Synonym Symbols:	S24; DBA3��
NCBI Protein Information:	40S ribosomal protein S24
UniProt Protein Name:	40S ribosomal protein S24
UniProt Synonym Protein Names:	Small ribosomal subunit protein eS24
Protein Family:	40S ribosomal protein
UniProt Gene Name:	RPS24��