Human QKI Recombinant Protein (RPPB4341)
- SKU:
- RPPB4341
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q96PU8
Frequently bought together:
Description
| Product Name: | Human QKI Recombinant Protein |
| Product Code: | RPPB4341 |
| Size: | 10µg |
| Species: | Human |
| Target: | QKI |
| Synonyms: | Hqk, hqkI, QK, QK1, QK3, Protein quaking, QuakingHomolog, KH Domain RNA Binding, RNA Binding Protein HQK, HKQ, KHDomain Containing, RNA Binding. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | QKI protein solution (0.25mg/ml) containing 20mM Tris-HClbuffer (pH 8.0), 0.2M NaCl, 50% glycerol, 2mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMVGEMET KEKPKPTPDY LMQLMNDKKL MSSLPNFCGI FNHLERLLDE EISRVRKDMY NDTLNGSTEK RSAELPDAVG PIVQLQEKLY VPVKEYPDFN FVGRILGPRG LTAKQLEAET GCKIMVRGKG SMRDKKKEEQ NRGKPNWEHL NEDLHVLITV EDAQNRAEIK LKRAVEEVKK LLVPAAEGED SLKKMQLMEL AILNGTYRDA NIKSPALAFS LAATAQAAPR IITGPAPVLP PAALRTPTPA GPTIMPLIRQ IQTAVMPNGT PHPTAAIVPP GPEAGLIYTP YEYPYTLAPA TSILEYPIEP SGVLGAVATK VRRHDMRVHP YQRIVTADRA ATGN |
KH Domain RNA Binding also known as QKI is aRNA-binding protein which regulates pre-mRNA splicing, export of mRNAs from thenucleus, protein translation, and mRNA stability. QKIis involved in myelinizationand oligodendrocyte differentiation, and it may play a role in schizophrenia.Defects or deletions in the QKIare linked with astrocytic tumors and may be implicated in the pathogenesis ofschizophrenia. Among the diseases associated with QKI are6q terminal deletion syndrome, and schizophrenia.
QKI Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 364 amino acids (1-341 a.a) and having a molecular mass of 40.1kDa.QKI is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | RNA-binding protein that plays a central role in myelinization (PubMed:16641098). Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Regulates target mRNA stability (PubMed:23630077). In addition, acts by regulating pre-mRNA splicing, mRNA export and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B. Regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia (PubMed:16641098). Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor. |
| NCBI Summary: | The protein encoded by this gene is an RNA-binding protein that regulates pre-mRNA splicing, export of mRNAs from the nucleus, protein translation, and mRNA stability. The encoded protein is involved in myelinization and oligodendrocyte differentiation and may play a role in schizophrenia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014] |
| UniProt Code: | Q96PU8 |
| NCBI GenInfo Identifier: | 74761039 |
| NCBI Gene ID: | 9444 |
| NCBI Accession: | Q96PU8.1 |
| UniProt Secondary Accession: | Q96PU8,Q2I375, Q5MJQ1, Q969L9, Q96EJ3, Q96KA3, Q96PU6 Q96PU7, Q9P0X6, Q9P0X7, Q9P0X8, Q9P0X9, |
| UniProt Related Accession: | Q96PU8 |
| Molecular Weight: | 35,131 Da |
| NCBI Full Name: | Protein quaking |
| NCBI Synonym Full Names: | QKI, KH domain containing RNA binding |
| NCBI Official Symbol: | QKI�� |
| NCBI Official Synonym Symbols: | QK; Hqk; QK1; QK3; hqkI�� |
| NCBI Protein Information: | protein quaking |
| UniProt Protein Name: | Protein quaking |
| Protein Family: | Protein quaking |
| UniProt Gene Name: | QKI�� |
| UniProt Entry Name: | QKI_HUMAN |
