Human NDEL1 Recombinant Protein (RPPB4073)
- SKU:
- RPPB4073
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9GZM8
Description
| Product Name: | Human NDEL1 Recombinant Protein |
| Product Code: | RPPB4073 |
| Size: | 10µg |
| Species: | Human |
| Target: | NDEL1 |
| Synonyms: | NudE Neurodevelopment Protein 1-Like 1, NUDEL, Mitosin-AssociatedProtein 1, Protein Nudel, EOPA, MITAP1, NudE Nuclear Distribution E Homolog (A.Nidulans)- Like 1, NudE NuclearDistribution Gene E Homolog (A. Nidulans)-Like 1, NDE1L1, NDE2, EndooligopeptidaseA, Mitosin-Associated Protein MITAP1, Nuclear Distribution Protein NudE-Like 1,NudE Nuclear Distribution E Homolog-Like 1, NudE Nuclear Distribution Gene EHomolog-Like 1, NDEL1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | NDEL1 protein solution (0.5mg/ml) containing 20mMTris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 80.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMDGEDIP DFSSLKEETA YWKELSLKYK QSFQEARDEL VEFQEGSRELEAELEAQLVQ AEQRNRDLQA DNQRLKYEVE ALKEKLEHQY AQSYKQVSVL EDDLSQTRAI KEQLHKYVRELEQANDDLER AKRATIVSLE DFEQRLNQAI ERNAFLESELDEKESLLVSV QRLKDEARDLRQELAVRERQ QEVTRKSAPS SPTLDCEKMD SAVQASLSLP ATPVGKGTEN TFPSPKAIPN GFGTSPLTPS ARISALNIVGDLLRKVGALE SKLAACRNFA KDQASRKSYI SGNVNCGVLN GNGTKFSRSG HTSFFDKGQE KVIFPTLFMG Q |
NudE Neurodevelopment Protein 1-Like 1 also known as NDEL1 is acoiled-coil protein which participates in multiple processes as well ascytoskeletal organization,cell signaling and neuron migration,outgrowth and maintenance. Alternativelyspliced transcript variantsencoding multiple isoforms have been observed for NDEL1, and a pseudogene ofthis gene is placed on thelong arm of chromosome X. One of the diseasesassociated with NDEL1 is iridocyclitis.
NDEL1 Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 351 amino acids (1-328 a.a) andhaving a molecular mass of 39.4kDa.NDEL1 is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.
| UniProt Protein Function: | NDEL1: Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL. Belongs to the nudE family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Protease; Microtubule-binding Chromosomal Location of Human Ortholog: 17p13.1 Cellular Component: axon hillock; kinetochore; microtubule; kinesin complex; centrosome; neurofilament cytoskeleton; cytoplasm; leading edge; nucleolus; nuclear envelope; spindle; cytosol Molecular Function:protein binding; microtubule binding; beta-tubulin binding; alpha-tubulin binding Biological Process: cell migration; positive regulation of axon regeneration; central nervous system neuron axonogenesis; positive regulation of axon extension; establishment of chromosome localization; neuron migration; nuclear envelope disassembly; proteolysis; microtubule nucleation; inner cell mass cell proliferation; retrograde axon cargo transport; chromosome segregation; mitotic centrosome separation; establishment of mitotic spindle orientation; centrosome localization; neurofilament cytoskeleton organization and biogenesis; vesicle transport along microtubule; cerebral cortex radially oriented cell migration; mitotic cell cycle |
| NCBI Summary: | This gene encodes a coiled-coil protein that plays a role in multiple processes including cytoskeletal organization, cell signaling and neuron migration, outgrowth and maintenance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome X. [provided by RefSeq, Mar 2012] |
| UniProt Code: | Q9GZM8 |
| NCBI GenInfo Identifier: | 74725006 |
| NCBI Gene ID: | 81565 |
| NCBI Accession: | Q9GZM8.1 |
| UniProt Secondary Accession: | Q9GZM8,Q86T80, Q8TAR7, Q9UH50, B3KP93, D3DTS0, J3QT32 |
| UniProt Related Accession: | Q9GZM8 |
| Molecular Weight: | 345 |
| NCBI Full Name: | Nuclear distribution protein nudE-like 1 |
| NCBI Synonym Full Names: | nudE neurodevelopment protein 1-like 1 |
| NCBI Official Symbol: | NDEL1�� |
| NCBI Official Synonym Symbols: | EOPA; NDE2; NUDEL; MITAP1; NDE1L1�� |
| NCBI Protein Information: | nuclear distribution protein nudE-like 1; protein Nudel; endooligopeptidase A; mitosin-associated protein 1; mitosin-associated protein MITAP1; nudE nuclear distribution E homolog-like 1; nudE nuclear distribution gene E homolog-like 1 |
| UniProt Protein Name: | Nuclear distribution protein nudE-like 1 |
| UniProt Synonym Protein Names: | Mitosin-associated protein 1 |
| UniProt Gene Name: | NDEL1�� |
| UniProt Entry Name: | NDEL1_HUMAN |
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