Human IGLL1 Recombinant Protein (RPPB3739)
- SKU:
- RPPB3739
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P15814
- Research Area:
- CD Antigens
Frequently bought together:
Description
| Product Name: | Human IGLL1 Recombinant Protein |
| Product Code: | RPPB3739 |
| Size: | 20µg |
| Species: | Human |
| Target: | IGLL1 |
| Synonyms: | 14.1, AGM2, CD179b, IGL1, IGL5, IGLJ14.1, IGLL, IGO, IGVPB, VPREB2, Immunoglobulin lambda-like polypeptide 1, CD179 antigen-like family member B, Ig lambda-5, Immunoglobulin omega polypeptide, Immunoglobulin-related protein 14.1, IGLL1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | IGLL1 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.4M urea and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSLLRPTAA SQSRALGPGA PGGSSRSSLR SRWGRFLLQR GSWTGPRCWP RGFQSKHNSV THVFGSGTQL TVLSQPKATP SVTLFPPSSE ELQANKATLV CLMNDFYPGI LTVTWKADGT PITQGVEMTT PSKQSNNKYA ASSYLSLTPE QWRSRRSYSC QVMHEGSTVE KTVAPAECS |
Immunoglobulin Lambda-Like Polypeptide 1 (IGLL1) is one of the substitute light chain subunits and is a part of the immunoglobulin gene superfamily which does not undergo rearrangement. Two transcript variants encoding diverse isoforms have been found for IGLL1. Mutations in IGLL1 can bring about B cell deficiency and agammaglobulinemia, an autosomal recessive disease in which few or no gamma globulins or antibodies are made.
IGLL1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 199 amino acids (38-213a.a.) and having a molecular mass of 21.5kDa. IGLL1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | IGLL1: Critical for B-cell development. Defects in IGLL1 are the cause of agammaglobulinemia type 2 (AGM2). It is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Secreted, signal peptide; SecretedChromosomal Location of Human Ortholog: 22q11.23Cellular Component: external side of plasma membrane; membraneMolecular Function: antigen bindingBiological Process: B cell receptor signaling pathway; complement activation, classical pathway; defense response to bacterium; immune response; innate immune response; phagocytosis, engulfment; phagocytosis, recognition; positive regulation of B cell activationDisease: Agammaglobulinemia 2, Autosomal Recessive |
| UniProt Protein Details: | |
| NCBI Summary: | The preB cell receptor is found on the surface of proB and preB cells, where it is involved in transduction of signals for cellular proliferation, differentiation from the proB cell to the preB cell stage, allelic exclusion at the Ig heavy chain gene locus, and promotion of Ig light chain gene rearrangements. The preB cell receptor is composed of a membrane-bound Ig mu heavy chain in association with a heterodimeric surrogate light chain. This gene encodes one of the surrogate light chain subunits and is a member of the immunoglobulin gene superfamily. This gene does not undergo rearrangement. Mutations in this gene can result in B cell deficiency and agammaglobulinemia, an autosomal recessive disease in which few or no gamma globulins or antibodies are made. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P15814 |
| NCBI GenInfo Identifier: | 123944 |
| NCBI Gene ID: | 3543 |
| NCBI Accession: | P15814.1 |
| UniProt Secondary Accession: | P15814,Q0P681 |
| UniProt Related Accession: | P15814 |
| Molecular Weight: | 8,574 Da |
| NCBI Full Name: | Immunoglobulin lambda-like polypeptide 1 |
| NCBI Synonym Full Names: | immunoglobulin lambda like polypeptide 1 |
| NCBI Official Symbol: | IGLL1�� |
| NCBI Official Synonym Symbols: | IGO; 14.1; AGM2; IGL1; IGL5; IGLL; IGVPB; CD179b; VPREB2; IGLJ14.1�� |
| NCBI Protein Information: | immunoglobulin lambda-like polypeptide 1 |
| UniProt Protein Name: | Immunoglobulin lambda-like polypeptide 1 |
| UniProt Synonym Protein Names: | CD179 antigen-like family member B; Ig lambda-5; Immunoglobulin omega polypeptide; Immunoglobulin-related protein 14.1; CD_antigen: CD179b |
| Protein Family: | Ig lambda chain C region |
| UniProt Gene Name: | IGLL1�� |
| UniProt Entry Name: | IGLL1_HUMAN |
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