Human HRASLS3 Recombinant Protein (RPPB1830)
- SKU:
- RPPB1830
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P53816
- Research Area:
- Enzymes
Description
| Product Name: | Human HRASLS3 Recombinant Protein |
| Product Code: | RPPB1830 |
| Size: | 50µg |
| Species: | Human |
| Target: | HRASLS3 |
| Synonyms: | PLA2G16, Phospholipase A2 Group XVI, AdPLA, H-REV107-1, HREV107, HREV107-3, MGC118754, HRAS-like suppressor 3, H-rev 107 protein homolog, Renal carcinoma antigen NY-REN-65, HRASLS3. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | The protein contains 20mM Tris-HCl buffer pH 8. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MRAPIPEPKP GDLIEIFRPF YRHWAIYVGD GYVVHLAPPS EVAGAGAASV MSALTDKAIV KKELLYDVAG SDKYQVNNKH DDKYSPLPCS KIIQRAEELV GQEVLYKLTS ENCEHFVNEL RYGVARSDQV RDV |
HRASLS3 is a tumor suppressor that takes part in dependent cell death. HRASLS3 is part of the class II tumor suppressor gene family and is involved in the regulation of differentiation and survival. HRASLS3 protein is expressed in a number of human tumors including ovarian carcinomas, lung carcinomas.
HRASLS3 Human Recombinant amino produced in E.Coli is a single, non-glycosylated polypeptide chain containing 133 amino acids (1-133) having a molecular mass of 14.9 kDa. The HRASLS3 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | PLA2G16: Exhibits PLA1/2 activity, catalyzing the calcium- independent hydrolysis of acyl groups in various phosphotidylcholines (PC) and phosphatidylethanolamine (PE). For most substrates, PLA1 activity is much higher than PLA2 activity. Specifically catalyzes the release of fatty acids from phospholipids in adipose tissue. N- and O- acylation activity is hardly detectable. Might decrease protein phosphatase 2A (PP2A) activity. Belongs to the H-rev107 family. |
| UniProt Protein Details: | Protein type:EC 3.1.1.4; EC 3.1.1.32; Membrane protein, integral Chromosomal Location of Human Ortholog: 11q12.3 Cellular Component: perinuclear region of cytoplasm; endoplasmic reticulum; integral to membrane; cytosol Molecular Function:phospholipase A2 activity; protein binding; phospholipase A1 activity Biological Process: phospholipid metabolic process; glycerophospholipid biosynthetic process; lipid catabolic process; negative regulation of cell cycle |
| UniProt Code: | P53816 |
| NCBI GenInfo Identifier: | 75517991 |
| NCBI Gene ID: | 11145 |
| NCBI Accession: | |
| UniProt Related Accession: | P53816,Q3MI98 |
| Molecular Weight: | 21,441 Da |
| NCBI Full Name: | PLA2G16 protein |
| NCBI Synonym Full Names: | phospholipase A2, group XVI |
| NCBI Official Symbol: | PLA2G16�� |
| NCBI Official Synonym Symbols: | AdPLA; HRSL3; HRASLS3; HREV107; HREV107-1; HREV107-3; MGC118754; H-REV107-1�� |
| NCBI Protein Information: | group XVI phospholipase A2; OTTHUMP00000237069; adipose-specific PLA2; HRAS-like suppressor 1; HRAS-like suppressor 3; H-rev 107 protein homolog; Ca-independent phospholipase A1/2; adipose-specific phospholipase A2; renal carcinoma antigen NY-REN-65 |
| UniProt Protein Name: | PLA2G16 protein |
| Protein Family: | HRAS-like suppressor |
| UniProt Gene Name: | PLA2G16�� |
| UniProt Entry Name: | Q3MI98_HUMAN |
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