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Human HNRNPC Recombinant Protein (RPPB3707)

SKU:
RPPB3707
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P07910
€309
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Description

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Product Name:Human HNRNPC Recombinant Protein
Product Code:RPPB3707
Size:5µg
Species:Human
Target:HNRNPC
Synonyms:Heterogeneous Nuclear Ribonucleoprotein C (C1/C2), HNRPC, hnRNP C1/C2, hnRNPC, C1, C2, SNRPC, MGC104306, MGC105117, MGC117353, MGC131677.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:The HNRNPC protein solution (0.25mg/ml) is formulated in 20mM Tris-HCl buffer (pH8.0), 200mM NaCl, 5mM DTT and 30% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MASNVTNKTD PRSMNSRVFI GNLNTLVVKK SDVEAIFSKY GKIVGCSVHK GFAFVQYVNE RNARAAVAGE DGRMIAGQVL DINLAAEPKV NRGKAGVKRS AAEMYGSSFD LDYDFQRDYY DRMYSYPARV PPPPPIARAV VPSKRQRVSG NTSRRGKSGF NSKSGQRGSS KSGKLKGDDL QAIKKELTQI KQKVDSLLEN LEKIEKEQSK QAVEMKNDKS EEEQSSSSVK KDETNVKMES EGGADDSAEE GDLLDDDDNE DRGDDQLELI KDDEKEAEEG EDDRDSANGE DDS

HNRNPC is a member of the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs) which are related to pre mRNAs in the nucleus and effect pre mRNA processing and other aspects of mRNA metabolism and transport. Although all of the hnRNPs are present in the nucleus, several hnRNPs travel between the nucleus and the cytoplasm. The hnRNP proteins have specific nucleic acid binding properties.

HNRNPC produced in E.Coli is a single, non-glycosylated polypeptide chain containing 313 amino acids (1-293a.a.) and having a molecular mass of 34.5kDa (Molecular weight on SDS-PAGE will appear higher). HNRNPC is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:hnRNP C1/C2: a heterogeneous nuclear ribonucleoprotein. May play a role in ribonucleosome assembly by neutralizing basic proteins such as A and B core hnRNP. Contains 1 RNA recognition motif (RRM) domain. Two alternatively spliced isoforms have been described.
UniProt Protein Details:

Protein type:Spliceosome; RNA-binding; RNA splicing

Chromosomal Location of Human Ortholog: 14q11.2

Cellular Component: cytosol; membrane; nuclear chromatin; nucleoplasm; nucleus; protein complex; spliceosome; telomerase holoenzyme complex

Molecular Function:identical protein binding; mRNA 3'-UTR binding; nucleosomal DNA binding; nucleotide binding; poly(U) binding; protein binding; RNA binding

Biological Process: ATP-dependent chromatin remodeling; cellular protein metabolic process; gene expression; negative regulation of telomere maintenance via telomerase; nuclear mRNA splicing, via spliceosome; osteoblast differentiation; post-translational protein modification; protein sumoylation; RNA splicing

NCBI Summary:This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene can act as a tetramer and is involved in the assembly of 40S hnRNP particles. Multiple transcript variants encoding at least two different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:P07910
NCBI GenInfo Identifier:108935845
NCBI Gene ID:3183
NCBI Accession:P07910.4
UniProt Secondary Accession:P07910,P22628, Q53EX2, Q59FD3, Q5FWE8, Q86SF8, Q86U45 Q96HK7, Q96HM4, Q96IY5, D3DS19, D3DS22,
UniProt Related Accession:P07910
Molecular Weight:27,822 Da
NCBI Full Name:Heterogeneous nuclear ribonucleoproteins C1/C2
NCBI Synonym Full Names:heterogeneous nuclear ribonucleoprotein C (C1/C2)
NCBI Official Symbol:HNRNPC��
NCBI Official Synonym Symbols:C1; C2; HNRNP; HNRPC; SNRPC��
NCBI Protein Information:heterogeneous nuclear ribonucleoproteins C1/C2
UniProt Protein Name:Heterogeneous nuclear ribonucleoproteins C1/C2
Protein Family:Heterogeneous nuclear ribonucleoprotein
UniProt Gene Name:HNRNPC��
UniProt Entry Name:HNRPC_HUMAN

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