Human HBG1 Recombinant Protein (RPPB3662)
- SKU:
- RPPB3662
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P69891
Description
| Product Name: | Human HBG1 Recombinant Protein |
| Product Code: | RPPB3662 |
| Size: | 10µg |
| Species: | Human |
| Target: | HBG1 |
| Synonyms: | HBGA, HBGR, HSGGL1, PRO2979, Hemoglobin subunit gamma-1, Gamma-1-globin, Hb F Agamma, Hemoglobin gamma-1 chain, Hemoglobin gamma-A chain, HBG1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | The HBG1 solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMGHFTEE DKATITSLWG KVNVEDAGGE TLGRLLVVYP WTQRFFDSFG NLSSASAIMG NPKVKAHGKK VLTSLGDATK HLDDLKGTFA QLSELHCDKL HVDPENFKLL GNVLVTVLAI HFGKEFTPEV QASWQKMVTA VASALSSRYH |
The gamma globin genes which are HBG1 and HBG2, usually expressed in the fetal liver, spleen and bone marrow. 2 gamma chains together along with 2 alpha chains comprise fetal hemoglobin (HbF) which is normally replaced by mature hemoglobin (HbA) at birth. Gamma chain production continues into adulthood in several beta-thalassemias and linked situations. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth.
HBG1 Human Recombinant produced in E. coli is a single polypeptide chain containing 170 amino acids (1-147) and having a molecular mass of 18kDa. HBG1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | HBG1: Gamma chains make up the fetal hemoglobin F, in combination with alpha chains. Belongs to the globin family. |
| UniProt Protein Details: | Protein type:Carrier Chromosomal Location of Human Ortholog: 11p15.5 Cellular Component: cytosol Biological Process: blood coagulation Disease: Fetal Hemoglobin Quantitative Trait Locus 1 |
| NCBI Summary: | The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P69891 |
| NCBI GenInfo Identifier: | 56749860 |
| NCBI Gene ID: | 3047 |
| NCBI Accession: | P69891.2 |
| UniProt Secondary Accession: | P69891,P02096, P62027, Q549G1, Q8TDA1, Q96FH7, |
| UniProt Related Accession: | P69891 |
| Molecular Weight: | 16,140 Da |
| NCBI Full Name: | Hemoglobin subunit gamma-1 |
| NCBI Synonym Full Names: | hemoglobin subunit gamma 1 |
| NCBI Official Symbol: | HBG1�� |
| NCBI Official Synonym Symbols: | HBGA; HBGR; HBG-T2; HSGGL1; PRO2979�� |
| NCBI Protein Information: | hemoglobin subunit gamma-1 |
| UniProt Protein Name: | Hemoglobin subunit gamma-1 |
| UniProt Synonym Protein Names: | Gamma-1-globin; Hb F Agamma; Hemoglobin gamma-1 chain; Hemoglobin gamma-A chain |
| Protein Family: | Hemoglobin |
| UniProt Gene Name: | HBG1�� |
| UniProt Entry Name: | HBG1_HUMAN |
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