Human FABP6 Recombinant Protein (RPPB3502)
- SKU:
- RPPB3502
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P51161
Description
| Product Name: | Human FABP6 Recombinant Protein |
| Product Code: | RPPB3502 |
| Size: | 25µg |
| Species: | Human |
| Target: | FABP6 |
| Synonyms: | I-BABP, ILBP, I-15P, I-BAP, ILBP3, ILLBP, I-BABP, I-BALB, FABP-6, Gastrotropin, Ileal lipid-binding protein, Intestinal 15 kDa protein, Intestinal bile acid-binding protein, Fatty acid-binding protein 6, FABP6. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless liquid formulation. |
| Formulation: | FABP6 His-Tag is supplied in 20mM Tris HCL pH=8, 0.5mM DTT and 50% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.Please avoid freeze thaw cycles. |
| Purity: | Greater than 95% as determined by SDS-PAGE. |
FABP6 also called ileal fatty acid binding protein, is part of the small family of highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABP6 cytosolic protein binds bile acid. FABP6 plays a role in fatty acid uptake, transport, and metabolism. FABP6 stimulates gastric acid and pepsinogen secretion. Seems to be able to bind to bile salts and bilirubins. FABP6 expression is restricted in the small intestine to the ileum where it is involved in the enterohepatic circulation of bile acids. Alternate transcription promoters generate 2 transcript variants, encoding a 128 aa and a 177 aa residue protein. Human FABP6 isoform 2 contains 128 amino acid residues and is acetylated on Ala2. FABP6 binds together fatty acids and bile acids and is directly involved in fatty acid transport and metabolism.
FABP6 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 128 amino acids and having a molecular mass of 18 kDa. FABP6 is fused to His tag at N-terminus and purified by standard chromatography techniques.
| UniProt Protein Function: | FABP6: Ileal protein which stimulates gastric acid and pepsinogen secretion. Seems to be able to bind to bile salts and bilirubins. Isoform 2 is essential for the survival of colon cancer cells to bile acid-induced apoptosis. Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. 2 isoforms of the human protein are produced by alternative promoter. |
| UniProt Protein Details: | Protein type:Lipid-binding Chromosomal Location of Human Ortholog: 5q33.3-q34 Cellular Component: cytoplasm; cytosol Molecular Function:transporter activity; lipid binding Biological Process: bile acid and bile salt transport; negative regulation of cell proliferation; bile acid metabolic process; lipid metabolic process; transmembrane transport |
| NCBI Summary: | This gene encodes the ileal fatty acid binding protein. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABP6 and FABP1 (the liver fatty acid binding protein) are also able to bind bile acids. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. Transcript variants generated by alternate transcription promoters and/or alternate splicing have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P51161 |
| NCBI GenInfo Identifier: | 1708457 |
| NCBI Gene ID: | 2172 |
| NCBI Accession: | P51161.2 |
| UniProt Secondary Accession: | P51161,Q07DR7, Q8TBI3, Q9UGI7, |
| UniProt Related Accession: | P51161 |
| Molecular Weight: | 128 |
| NCBI Full Name: | Gastrotropin |
| NCBI Synonym Full Names: | fatty acid binding protein 6, ileal |
| NCBI Official Symbol: | FABP6�� |
| NCBI Official Synonym Symbols: | ILBP; I-15P; I-BAP; ILBP3; ILLBP; I-BABP; I-BALB�� |
| NCBI Protein Information: | gastrotropin; GT; intestinal 15 kDa protein; ileal lipid-binding protein; illeal lipid-binding protein; ileal bile acid binding protein |
| UniProt Protein Name: | Gastrotropin |
| UniProt Synonym Protein Names: | Fatty acid-binding protein 6; Ileal lipid-binding protein; ILBP; Intestinal 15 kDa protein; I-15P; Intestinal bile acid-binding protein; I-BABP |
| Protein Family: | Gastrotropin |
| UniProt Gene Name: | FABP6�� |
| UniProt Entry Name: | FABP6_HUMAN |
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