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Nanodisc Human CLDN4-Strep Protein (HDFP820)

SKU:
HDFP820
Size:
10μg
Target:
CLDN4
Tag:
C-Flag&Strep Tag
Expression Host:
HEK293
Conjugate:
Unconjugated
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Description

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Product Name:Nanodisc Human CLDN4-Strep Protein
SKU:HDFP820
Size:10μg
Target:CLDN4
Tag:C-Flag&Strep Tag
Expression Host:HEK293
Conjugate:Unconjugated
Synonyms:CPE-R; CPER; CPETR; CPETR1; hCPE-R; WBSCR8
Protein Families:Druggable Genome, Transmembrane.
Protein Description:Human CLDN4-Strep full length protein-synthetic nanodisc
Protein Pathways:Cell adhesion molecules (CAMs), Leukocyte transendothelial migration, Tight junction.
Molecular Weight:The human full length CLDN4-Strep protein has a MW of 22.1 kDa

The protein belongs to the claudin family. Claudins are integral membrane proteins that are components of the epithelial cell tight junctions, which regulate movement of solutes and ions through the paracellular space. This protein is a high-affinity receptor for Clostridium perfringens enterotoxin (CPE) and may play a role in internal organ development and function during pre- and postnatal life. This gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems.

Uniprot ID:O14493
Formulation & Reconstitution:Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions. Do not use solvents with a pH below 6.5 or those containing high concentrations of divalent metal ions (greater than 5 mM) in subsequent experiments.
Storage & Shipping:Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C(Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Usage:Research use only

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