Human CD300A Recombinant Protein (RPPB3115)
- SKU:
- RPPB3115
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9UGN4
- Research Area:
- CD Antigens
Description
| Product Name: | Human CD300A Recombinant Protein |
| Product Code: | RPPB3115 |
| Size: | 10µg |
| Species: | Human |
| Target: | CD300A |
| Synonyms: | CD300a Molecule, CD300a Antigen, IRp60, CD300 Antigen-Like Family Member A, NK Inhibitory Receptor, Immunoglobulin Superfamily Member 12, CMRF35-Like Molecule 8, CMRF35-H, Inhibitory Receptor Protein 60, CMRF-35-H9, CMRF-35H, CLM-8, IRC1, IRC2, CMRF35H Leukocyte Immunoglobulin-Like Receptor, Leukocyte Membrane Antigen, IgSF12. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | The CD300A solution contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 1mM DTT and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks.�Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSLSKCRTV AGPVGGSLSV QCPYEKEHRT LNKYWCRPPQ IFLCDKIVET KGSAGKRNGR VSIRDSPANL SFTVTLENLT EEDAGTYWCG VDTPWLRDFH DPVVEVEVSV FPAS |
CD300A belongs to the CD300 family and contains 1 Ig-like V-type (immunoglobulin-like) domain. The protein is expressed not only by natural killer (NK) cells but also by T-cell subsets, B-cells, dendritic cells, mast cells, granulocytes and monocytes. CD300A is inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation.
CD300A Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 134 amino acids (18-128) and having a molecular mass of 14.7kDa.CD300A is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | MAIR-I: Inhibitory receptor which may contribute to the down- regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation. Belongs to the CD300 family. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Immunoglobulin superfamily; Membrane protein, integral Chromosomal Location of Human Ortholog: 17q25.1 Cellular Component: membrane; plasma membrane Molecular Function:phosphatidylethanolamine binding; phosphatidylserine binding; protein binding Biological Process: negative regulation of B cell proliferation; negative regulation of B cell receptor signaling pathway; negative regulation of fibroblast proliferation; negative regulation of MAP kinase activity; negative regulation of mast cell activation during immune response; negative regulation of mast cell degranulation; negative regulation of MyD88-dependent toll-like receptor signaling pathway; negative regulation of NK T cell activation; negative regulation of phagocytosis, engulfment; neutrophil degranulation; positive regulation of phosphoprotein phosphatase activity; regulation of immune response; regulation of T cell receptor signaling pathway |
| NCBI Summary: | This gene encodes a member of the CD300 glycoprotein family of cell surface proteins found on leukocytes involved in immune response signaling pathways. This gene is located on chromosome 17 in a cluster with all but one of the other family members. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012] |
| UniProt Code: | Q9UGN4 |
| NCBI GenInfo Identifier: | 126302534 |
| NCBI Gene ID: | 11314 |
| NCBI Accession: | Q9UGN4.2 |
| UniProt Secondary Accession: | Q9UGN4,O95100, Q9HD97, Q9P0F3, Q9UBK4, Q9UMS9, Q9UMT0 A8MW96, |
| UniProt Related Accession: | Q9UGN4 |
| Molecular Weight: | 33kDa |
| NCBI Full Name: | CMRF35-like molecule 8 |
| NCBI Synonym Full Names: | CD300a molecule |
| NCBI Official Symbol: | CD300A�� |
| NCBI Official Synonym Symbols: | IRC1; IRC2; CLM-8; IRp60; IGSF12; CMRF35H; CMRF-35H; CMRF35-H; CMRF35H9; CMRF35-H9; IRC1/IRC2; CMRF-35-H9�� |
| NCBI Protein Information: | CMRF35-like molecule 8 |
| UniProt Protein Name: | CMRF35-like molecule 8 |
| UniProt Synonym Protein Names: | CD300 antigen-like family member A; CMRF-35-H9; CMRF35-H9; CMRF35-H; IRC1/IRC2; Immunoglobulin superfamily member 12; IgSF12; Inhibitory receptor protein 60; IRp60; NK inhibitory receptor; CD_antigen: CD300a |
| Protein Family: | CMRF35-like molecule |
| UniProt Gene Name: | CD300A�� |
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