Human CBX1 Recombinant Protein (RPPB2988)
- SKU:
- RPPB2988
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P83916
Description
| Product Name: | Human CBX1 Recombinant Protein |
| Product Code: | RPPB2988 |
| Size: | 20µg |
| Species: | Human |
| Target: | CBX1 |
| Synonyms: | Chromobox homolog 1, CBX, M31, HP1-BETA, HP1Hs-beta, MOD1, Heterochromatin protein 1 homolog beta, Modifier 1 protein, p25beta, Chromobox homolog 1 (Drosophila HP1 beta), Heterochromatin protein p25. |
| Source: | Escherichia Coli |
| Physical Appearance: | CBX1 is supplied as a sterile filtered clear solution. |
| Formulation: | CBX1 protein 1mg/ml is supplied in 20mM Tris-HCl, pH-8, 0.1M NaCl, 2mM DTT and 20% Glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGKKQNKKKV EEVLEEEEEE YVVEKVLDRR VVKGKVEYLL KWKGFSDEDN TWEPEENLDC PDLIAEFLQS QKTAHETDKS EGGKRKADSD SEDKGEESKP KKKKEESEKP RGFARGLEPE RIIGATDSSG ELMFLMKWKN SDEADLVPAK EANVKCPQVV ISFYEERLTW HSYPSEDDDK KDDKN |
CBX1 is an enriched heterochromatin which belongs to the heterochromatin protein family. The centromeres related CBX1 identifies and binds histone H3 tails methylated at 'Lys-9', causing epigenetic repression. Collaboration with lamin B receptor (LBR) can impact the relations between the heterochromatin and the inner nuclear membrane. CBX1 has a vital part in the epigenetic control of chromatin structure and gene expression.
CBX1 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 205 amino acids (1-185) and having a molecular mass of 23.6kDa (molecular weight on SDS-PAGE will appear higher).The CBX1 is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CBX1: Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane. Homodimer. Interacts directly with CHAF1A, EMSY, LBR, TIF1/TIF1A and TRIM28/TIF1B PXVXL motif via the chromoshadow domain. Interacts directly with histone H3 methylated at 'Lys-9' via the chromo domain. Interacts with SUV39H1 and SETDB1, SUV420H1 and SUV420H2. Interacts with PRDM6. Interacts with POGZ. Interacts with CHAMP1. Interacts with ASXL1. Expressed in all adult and embryonic tissues. |
| UniProt Protein Details: | Protein type:Transcription factor Chromosomal Location of Human Ortholog: 17q21.32 Cellular Component: nucleoplasm; centric heterochromatin; male pronucleus; female pronucleus; spindle; nuclear heterochromatin; chromatin; chromosome, pericentric region; chromocenter Molecular Function:protein binding; protein homodimerization activity; enzyme binding; chromatin binding Biological Process: negative regulation of transcription, DNA-dependent |
| NCBI Summary: | This gene is a member of the paired box (PAX) family of transcription factors. Members of the PAX family typically contain a paired box domain and a paired-type homeodomain. These genes play critical roles during fetal development. Mutations in paired box gene 3 are associated with Waardenburg syndrome, craniofacial-deafness-hand syndrome, and alveolar rhabdomyosarcoma. The translocation t(2;13)(q35;q14), which represents a fusion between PAX3 and the forkhead gene, is a frequent finding in alveolar rhabdomyosarcoma. Alternative splicing results in transcripts encoding isoforms with different C-termini. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P83916 |
| NCBI GenInfo Identifier: | 48428808 |
| NCBI Gene ID: | 5077 |
| NCBI Accession: | P83916.1 |
| UniProt Related Accession: | P23760 |
| Molecular Weight: | |
| NCBI Full Name: | Chromobox protein homolog 1 |
| NCBI Synonym Full Names: | paired box 3 |
| NCBI Official Symbol: | PAX3�� |
| NCBI Official Synonym Symbols: | WS1; WS3; CDHS; HUP2�� |
| NCBI Protein Information: | paired box protein Pax-3 |
| UniProt Protein Name: | Chromobox protein homolog 1 |
| UniProt Synonym Protein Names: | HP1Hsbeta; Heterochromatin protein 1 homolog beta; HP1 beta; Heterochromatin protein p25; M31; Modifier 1 protein; p25beta |
| Protein Family: | Chromobox protein |
| UniProt Gene Name: | CBX1�� |
| UniProt Entry Name: | CBX1_HUMAN |
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