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Human BLVRA Recombinant Protein (RPPB1448)

SKU:
RPPB1448
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P53004
Research Area:
Enzymes
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Description

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Product Name:Human BLVRA Recombinant Protein
Product Code:RPPB1448
Size:50µg
Species:Human
Target:BLVRA
Synonyms:Biliverdin reductase A, BVR A, Biliverdin-IX alpha-reductase, BLVRA, BLVR, BVR, BVRA.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The BLVRA solution contains 20mM Tris-HCl buffer (pH8.0) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MAEPERKFGV VVVGVGRAGS VRMRDLRNPH PSSAFLNLIG FVSRRELGSI DGVQQISLED ALSSQEVEVA YICSESSSHE DYIRQFLNAG KHVLVEYPMT LSLAAAQELW ELAEQKGKVL HEEHVELLME EFAFLKKEVV GKDLLKGSLL FTAGPLEEER FGFPAFSGIS RLTWLVSLFGELSLVSATLE ERKEDQYMKM TVCLETEKKS PLSWIEEKGP GLKRNRYLSF HFKSGSLENV PNVGVNKNIF LKDQNIFVQK LLGQFSEKEL AAEKKRILHC LGLAEEIQKY CCSRK

Biliverdin reductase A (BLVRA) is a member of the gfo/idh/mocA family. BLVRA is an enzyme that converts biliverdin to bilirubin, converting a double-bond between the second and third pyrrole ring into a single-bond. BLVRA reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the simultaneous oxidation of a NADH or NADPH cofactor (Bilirubin + NAD(P)+ = biliverdin + NAD(P)H ).BLVRA is a regulator for induction of activating transcription factor-2 and heme oxygenase-1. Furthermore, BLVRA enhances the role of HO-1 in cytoprotection and provides cytoprotection independent of heme degradation. In addition, Bilirubin while acting as a cytoprotective antioxidant is itself oxidized to biliverdin and subsequently recycled by biliverdin reductase back to bilirubin.

BLVRA Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 295 amino acids (3-296 a.a. and Methionine at N-terminus) and having a molecular mass of 33.3kDa (molecular weight on SDS-PAGE will shift up).The BLVRA is purified by proprietary chromatographic techniques.

UniProt Protein Function:BVR: Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor. Monomer. Liver. Belongs to the Gfo/Idh/MocA family. Biliverdin reductase subfamily.
UniProt Protein Details:

Protein type:Oxidoreductase; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; EC 1.3.1.24; ATYPICAL group; BLVRA family

Chromosomal Location of Human Ortholog: 7p13

Cellular Component: cytosol

Molecular Function:zinc ion binding; biliverdin reductase activity

Biological Process: heme catabolic process; porphyrin metabolic process

Disease: Hyperbiliverdinemia

NCBI Summary:The protein encoded by this gene belongs to the biliverdin reductase family, members of which catalyze the conversion of biliverdin to bilirubin in the presence of NADPH or NADH. Mutations in this gene are associated with hyperbiliverdinemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2011]
UniProt Code:P53004
NCBI GenInfo Identifier:23830892
NCBI Gene ID:644
NCBI Accession:P53004.2
UniProt Related Accession:P53004
Molecular Weight:
NCBI Full Name:Biliverdin reductase A
NCBI Synonym Full Names:biliverdin reductase A
NCBI Official Symbol:BLVRA��
NCBI Official Synonym Symbols:BVR; BLVR; BVRA��
NCBI Protein Information:biliverdin reductase A
UniProt Protein Name:Biliverdin reductase A
UniProt Synonym Protein Names:Biliverdin-IX alpha-reductase
UniProt Gene Name:BLVRA��
UniProt Entry Name:BIEA_HUMAN

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