Nanodisc Human ADRB3-Strep Protein (HDFP919)
- SKU:
- HDFP919
- Size:
- 10μg
- Target:
- ADRB3
- Tag:
- C-Flag&Strep Tag
- Expression Host:
- HEK293
- Conjugate:
- Unconjugated
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Description
| Product Name: | Nanodisc Human ADRB3-Strep Protein |
| SKU: | HDFP919 |
| Size: | 10μg |
| Target: | ADRB3 |
| Tag: | C-Flag&Strep Tag |
| Expression Host: | HEK293 |
| Conjugate: | Unconjugated |
| Synonyms: | BETA3AR |
| Protein Families: | GPCR, Transmembrane, Druggable Genome. |
| Protein Description: | Human ADRB3-Strep full length protein-synthetic nanodisc |
| Protein Pathways: | Calcium regulation in cardiac cells, GPCRDB Class A Rhodopsin-like, Monoamine GPCRs, Cancer, Metabolic and Obesity, Insulin Signaling Pathway. |
| Molecular Weight: | The human full length ADRB3-Strep protein has a MW of 43.5 kDa |
The protein encoded by this gene belongs to the family of beta adrenergic receptors, which mediate catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor is located mainly in the adipose tissue and is involved in the regulation of lipolysis and thermogenesis. Obesity and bodyweight-related disorders are correlated with certain polymorphisms in three subtypes of beta-adrenoceptor, among them, the ADRB3 gene.[provided by RefSeq, Oct 2019]
| Uniprot ID: | P13945 |
| Formulation & Reconstitution: | Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions. Do not use solvents with a pH below 6.5 or those containing high concentrations of divalent metal ions (greater than 5 mM) in subsequent experiments. |
| Storage & Shipping: | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Usage: | Research use only |
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