Nanodisc Human ACHG-Strep Protein (HDFP1422)
- SKU:
- HDFP1422
- Size:
- 10μg
- Target:
- ACHG
- Tag:
- C-Flag&Strep Tag
- Expression Host:
- HEK293
- Conjugate:
- Unconjugated
Description
| Product Name: | Nanodisc Human ACHG-Strep Protein |
| SKU: | HDFP1422 |
| Size: | 10μg |
| Target: | ACHG |
| Tag: | C-Flag&Strep Tag |
| Expression Host: | HEK293 |
| Conjugate: | Unconjugated |
| Synonyms: | ACHRG |
| Protein Families: | Ion Channels: Cys-loop Receptors. |
| Protein Description: | Human ACHG-Strep full length protein-synthetic nanodisc |
| Molecular Weight: | The human full length ACHG-Strep protein has a MW of 57.9 kDa |
The mammalian muscle-type acetylcholine receptor is a transmembrane pentameric glycoprotein with two alpha subunits, one beta, one delta, and one epsilon (in adult skeletal muscle) or gamma (in fetal and denervated muscle) subunit. This gene, which encodes the gamma subunit, is expressed prior to the thirty-third week of gestation in humans. The gamma subunit of the acetylcholine receptor plays a role in neuromuscular organogenesis and ligand binding and disruption of gamma subunit expression prevents the correct localization of the receptor in cell membranes. Mutations in this gene cause Escobar syndrome and a lethal form of multiple pterygium syndrome. Muscle-type acetylcholine receptor is the major antigen in the autoimmune disease myasthenia gravis.[provided by RefSeq, Sep 2009]
| Uniprot ID: | P07510 |
| Formulation & Reconstitution: | Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions. Do not use solvents with a pH below 6.5 or those containing high concentrations of divalent metal ions (greater than 5 mM) in subsequent experiments. |
| Storage & Shipping: | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Usage: | Research use only |
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