The HSD17B6 Polyclonal Antibody (CAB14262) is a valuable tool for researchers studying the HSD17B6 enzyme, which plays a crucial role in steroid metabolism and hormone regulation. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the HSD17B6 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it ideal for investigations in the fields of endocrinology, reproductive biology, and metabolic disorders.
HSD17B6 is a key enzyme involved in the biosynthesis and metabolism of steroid hormones, including testosterone and estrogen. Dysregulation of its activity has been linked to various hormonal imbalances, reproductive disorders, and hormone-dependent cancers. Research on HSD17B6 is essential for understanding the mechanisms underlying these conditions and for developing targeted therapies to treat them. By using the HSD17B6 Polyclonal Antibody, scientists can enhance their studies on steroid hormone metabolism and its implications for human health.
Product Name:
HSD17B6 Rabbit Polyclonal Antibody
SKU:
CAB14262
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 178-317 of human HSD17B6 (NP_003716.2).
Early endosome membrane, Lumenal side, Microsome membrane, Peripheral membrane protein.
Calculated MW:
36kDa
Observed MW:
36kDa
The protein encoded by this gene has both oxidoreductase and epimerase activities and is involved in androgen catabolism. The oxidoreductase activity can convert 3 alpha-adiol to dihydrotestosterone, while the epimerase activity can convert androsterone to epi-androsterone. Both reactions use NAD+ as the preferred cofactor. This gene is a member of the retinol dehydrogenase family.
Purification Method:
Affinity purification
Gene ID:
8630
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using HSD17B6 Rabbit pAb (CAB14262) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
