The HSD17B14 Polyclonal Antibody (PACO40230) is a vital tool for researchers studying the HSD17B14 protein, an enzyme involved in steroid metabolism. This antibody, generated in rabbits, exhibits high specificity for human samples and has been rigorously validated for Western blot applications. By binding to the HSD17B14 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an ideal choice for investigations in endocrinology and cancer research.HSD17B14, also known as hydroxysteroid (17-beta) dehydrogenase 14, plays a key role in the biosynthesis of steroid hormones and has been implicated in various physiological processes, including reproductive function and lipid metabolism.
Dysregulation of HSD17B14 has been associated with hormone-dependent cancers and metabolic disorders, highlighting its potential as a therapeutic target. Understanding the function of HSD17B14 is essential for developing targeted treatments for these conditions and advancing our knowledge of steroid hormone biology.
Antibody Name:
HSD17B14 Antibody (PACO40230)
Antibody SKU:
PACO40230
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:1000-1:5000
Species Reactivity:
Human, Mouse
Immunogen:
Recombinant Human 17-beta-hydroxysteroid dehydrogenase 14 protein (1-270AA)
Western blot. All lanes: HSD17B14 antibody at 2µg/ml + Mouse kidney tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 29 kDa. Observed band size: 29 kDa.
Background:
Has NAD-dependent 17-beta-hydroxysteroid dehydrogenase activity. Converts oestradiol to oestrone. The physiological substrate is not known. Acts on oestradiol and 5-androstene-3-beta,17-beta-diol (in vitro).
Synonyms:
17-beta-hydroxysteroid dehydrogenase 14 (17-beta-HSD 14) (EC 1.1.1.-) (17-beta-hydroxysteroid dehydrogenase DHRS10) (Dehydrogenase/reductase SDR family member 10) (Retinal short-chain dehydrogenase/reductase retSDR3) (Short chain dehydrogenase/reductase family 47C member 1), HSD17B14, DHRS10 SDR3 SDR47C1
UniProt Protein Function:
HSD17B14: Has NAD-dependent 17-beta-hydroxysteroid dehydrogenase activity. Converts oestradiol to oestrone. The physiological substrate is not known. Acts on oestradiol and 5-androstene-3- beta,17-beta-diol (in vitro). Belongs to the short-chain dehydrogenases/reductases (SDR) family.Protein type: EC 1.1.1.-; OxidoreductaseChromosomal Location of Human Ortholog: 19q13.33Cellular Component: cytosolMolecular Function: estradiol 17-beta-dehydrogenase activity; identical protein binding; protein binding; testosterone 17-beta-dehydrogenase (NADP+) activityBiological Process: estrogen biosynthetic process; steroid catabolic process
UniProt Protein Details:
NCBI Summary:
17-beta-hydroxysteroid dehydrogenases, such as HSD17B14, are primarily involved in metabolism of steroids at the C17 position and also of other substrates, such as fatty acids, prostaglandins, and xenobiotics (Lukacik et al., 2007 [PubMed 17067289]).[supplied by OMIM, Jun 2009]
17-beta-hydroxysteroid dehydrogenase DHRS10; Dehydrogenase/reductase SDR family member 10; Retinal short-chain dehydrogenase/reductase retSDR3; Short chain dehydrogenase/reductase family 47C member 1
