The HIST2H2AC Polyclonal Antibody (PACO27377) is a valuable tool for researchers studying histone proteins and their role in chromatin structure and gene regulation. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. It specifically targets the HIST2H2AC protein, allowing for precise detection and analysis in various cell types.Histone proteins play a crucial role in packaging DNA into chromatin and modulating gene expression. The unique properties of HIST2H2AC make it a key player in epigenetic regulation and cellular processes such as DNA repair and transcription.
By studying this histone variant, researchers can gain insights into how chromatin dynamics impact various biological pathways.The HIST2H2AC Polyclonal Antibody is a versatile tool for investigating histone modifications, chromatin remodeling, and gene regulation processes. Its specificity and sensitivity make it an essential reagent for studies in epigenetics, cancer biology, and developmental biology. By understanding the functions of histone proteins like HIST2H2AC, researchers can uncover potential therapeutic targets for diseases linked to aberrant chromatin structure and gene expression.
Antibody Name:
HIST2H2AC Antibody (PACO27377)
Antibody SKU:
PACO27377
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Histone H2A type 2-C protein (2-129AA)
Immunohistochemistry of paraffin-embedded human testis tissue using PACO27377 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO27377 at dilution of 1:100.
Background:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Synonyms:
Histone H2A type 2-C (Histone H2A-GL101) (Histone H2A/q), HIST2H2AC, H2AFQ
UniProt Protein Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
UniProt Protein Details:
NCBI Summary:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
