GZMM Antibody (PACO51602)
- SKU:
- PACO51602
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
GZMM Antibody (PACO51602)
The GZMM Antibody (PAC051602) is a powerful tool for researchers studying GZMM, a protein involved in immune regulation and defense against pathogens. This polyclonal antibody, produced in rabbits, exhibits high reactivity with human samples and is well-suited for use in Western blot applications. By binding specifically to the GZMM protein, this antibody allows for precise detection and analysis in a variety of cell types, making it an ideal choice for investigations in immunology and infectious disease research.
GZMM, also known as Granzyme M, plays a crucial role in the immune system by promoting apoptosis in infected or abnormal cells. Its function in immune defense highlights its potential as a target for studying diseases such as viral infections, cancer, and autoimmune disorders. Investigating the role of GZMM can provide valuable insights into immune responses and contribute to the development of novel therapeutic strategies for combatting a range of health conditions.
| Antibody Name: | GZMM Antibody (PACO51602) |
| Antibody SKU: | PACO51602 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Granzyme M protein (98-243AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human lung tissue using PACO51602 at dilution of 1:100. |
 | Immunofluorescent analysis of MCF-7 cells using PACO51602 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Cleaves peptide substrates after methionine, leucine, and norleucine. Physiological substrates include EZR, alpha-tubulins and the apoptosis inhibitor BIRC5/Survivin. Promotes caspase activation and subsequent apoptosis of target cells. |
| Synonyms: | Granzyme M (EC 3.4.21) (Met-1 serine protease) (Hu-Met-1) (Met-ase) (Natural killer cell granular protease), GZMM, MET1 |
| UniProt Protein Function: | GZMM: Cleaves peptide substrates after methionine, leucine, and norleucine. Physiological substrates include EZR, alpha- tubulins and the apoptosis inhibitor BIRC5/Survivin. Promotes caspase activation and subsequent apoptosis of target cells. Belongs to the peptidase S1 family. Granzyme subfamily. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; EC 3.4.21.-; Secreted; Protease Chromosomal Location of Human Ortholog: 19p13.3 Cellular Component: membrane Molecular Function:protein binding; serine-type endopeptidase activity; serine-type peptidase activity Biological Process: cell death |
| NCBI Summary: | Human natural killer (NK) cells and activated lymphocytes express and store a distinct subset of neutral serine proteases together with proteoglycans and other immune effector molecules in large cytoplasmic granules. These serine proteases are collectively termed granzymes and include 4 distinct gene products: granzyme A, granzyme B, granzyme H, and the protein encoded by this gene, granzyme M. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012] |
| UniProt Code: | P51124 |
| NCBI GenInfo Identifier: | 296434527 |
| NCBI Gene ID: | 3004 |
| NCBI Accession: | P51124.2 |
| UniProt Related Accession: | P51124 |
| Molecular Weight: | 27,545 Da |
| NCBI Full Name: | Granzyme M |
| NCBI Synonym Full Names: | granzyme M |
| NCBI Official Symbol: | GZMMÂ Â |
| NCBI Official Synonym Symbols: | MET1; LMET1Â Â |
| NCBI Protein Information: | granzyme M |
| UniProt Protein Name: | Granzyme M |
| UniProt Synonym Protein Names: | Met-1 serine protease; Hu-Met-1; Met-ase; Natural killer cell granular protease |
| Protein Family: | Granzyme |
| UniProt Gene Name: | GZMMÂ Â |
| UniProt Entry Name: | GRAM_HUMAN |
| Antibodies | ELISA Kits |
| GZMM Antibody (PACO07422) | Human Granzyme M ELISA Kit |
| GZMM Antibody (PACO09656) | Human Granzyme M (GZMM) ELISA Kit |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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