GTPBP3 Antibody (PACO09640)
- SKU:
- PACO09640
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
GTPBP3 Antibody (PACO09640)
The GTPBP3 Polyclonal Antibody (PACO09640) is a valuable tool for researchers studying the GTPBP3 protein, which is involved in mitochondrial function and RNA metabolism. This antibody, produced in rabbits, has high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the GTPBP3 protein, this antibody enables researchers to detect and analyze GTPBP3 expression in various cell types, making it a versatile tool for studies in molecular biology and mitochondrial research.GTPBP3, a member of the GTP-binding protein family, plays a critical role in mitochondrial RNA translation and metabolism. Dysfunction of GTPBP3 has been implicated in various mitochondrial disorders and diseases, highlighting the importance of understanding its function and regulation.
By investigating the role of GTPBP3 in cellular processes, researchers can gain insights into mitochondrial biology and potentially develop new therapeutic strategies for mitochondrial-related disorders.Overall, the GTPBP3 Polyclonal Antibody is a valuable resource for researchers interested in exploring the role of the GTPBP3 protein in mitochondrial function and RNA metabolism. Its high reactivity and specificity make it an ideal tool for furthering our understanding of mitochondrial biology and its implications for human health.
| Antibody Name: | GTPBP3 Antibody (PACO09640) |
| Antibody SKU: | PACO09640 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Human GTPBP3 |
| Form: | Liquid |
| Storage Buffer: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| Purification Method: | Antigen Affinity Purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | GTP binding protein 3 (mitochondrial);GTPBP3;FLJ14700;GTPBG3;MSS1;MTGP1;THDF1 ; |
| UniProt Protein Function: | GTPBP3: GTPase involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs (Probable). Belongs to the Era/MnmE GTP-binding protein family. MnmE subfamily. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 19p13.11 Cellular Component: mitochondrion; nucleus Molecular Function:GTPase activity; GTP binding Biological Process: tRNA modification Disease: Combined Oxidative Phosphorylation Deficiency 23 |
| NCBI Summary: | This locus encodes a GTP-binding protein. The encoded protein is localized to the mitochondria and may play a role in mitochondrial tRNA modification. Polymorphisms at this locus may be associated with severity of aminoglycoside-induced deafness, a disease associated with a mutation in the 12S rRNA. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Sep 2010] |
| UniProt Code: | Q969Y2 |
| NCBI GenInfo Identifier: | 313104112 |
| NCBI Gene ID: | 84705 |
| NCBI Accession: | Q969Y2.2 |
| UniProt Secondary Accession: | Q969Y2,Q8TCY6, Q8WUW9, Q969G4, Q9BX61, A6NFH1, A6NIG5 A6NKR4, A8K7B4, B7Z4V8, |
| UniProt Related Accession: | Q969Y2 |
| Molecular Weight: | 492 |
| NCBI Full Name: | tRNA modification GTPase GTPBP3, mitochondrial |
| NCBI Synonym Full Names: | GTP binding protein 3 (mitochondrial) |
| NCBI Official Symbol: | GTPBP3Â Â |
| NCBI Official Synonym Symbols: | MSS1; MTGP1; THDF1; GTPBG3Â Â |
| NCBI Protein Information: | tRNA modification GTPase GTPBP3, mitochondrial; mitochondrial GTP-binding protein 1 |
| UniProt Protein Name: | tRNA modification GTPase GTPBP3, mitochondrial |
| UniProt Synonym Protein Names: | GTP-binding protein 3; Mitochondrial GTP-binding protein 1 |
| Protein Family: | tRNA modification GTPase |
| UniProt Gene Name: | GTPBP3Â Â |
| UniProt Entry Name: | GTPB3_HUMAN |
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