GSTM4 Rabbit Polyclonal Antibody (CAB7434)
- SKU:
- CAB7434
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | GSTM4 Rabbit Polyclonal Antibody |
SKU: | CAB7434 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-218 of human GSTM4 (NP_000841.1). |
Sequence: | MSMT LGYW DIRG LAHA IRLL LEYT DSSY EEKK YTMG DAPD YDRS QWLN EKFK LGLD FPNL PYLI DGAH KITQ SNAI LCYI ARKH NLCG ETEE EKIR VDIL ENQA MDVS NQLA RVCY SPDF EKLK PEYL EELP TMMQ HFSQ FLGK RPWF VGDK ITFV DFLA YDVL DLHR IFEP NCLD AFPN LKDF ISRF EGLE KISA YMKS SRFL PKPL YTRV AVWG NK |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | GTM4; GSTM4-4; GSTM4 |
Positive Sample: | SW480,NCI-H460,Mouse liver,Mouse lung |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm. |
Calculated MW: | 26kDa |
Observed MW: | 26-34kDa |
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Diversification of these genes has occurred in regions encoding substrate-binding domains, as well as in tissue expression patterns, to accommodate an increasing number of foreign compounds. Multiple transcript variants, each encoding a distinct protein isoform, have been identified.
Purification Method: | Affinity purification |
Gene ID: | 2948 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |