The GPR132 Polyclonal Antibody (PACO04015) is a valuable tool for researchers studying GPR132, a G protein-coupled receptor involved in various biological processes, including inflammation and immune responses. This rabbit-derived antibody is highly specific to human samples, making it an excellent choice for Western blot applications. By binding to the GPR132 protein, this antibody enables precise detection and analysis in a variety of cell types, making it ideal for studies in immunology, inflammation, and cancer research.
GPR132, also known as G2A, has been linked to the regulation of inflammatory responses and immune cell activation, highlighting its potential as a therapeutic target for diseases such as cancer, autoimmune disorders, and inflammatory conditions. Understanding the functions of GPR132 is essential for developing targeted therapies that modulate immune responses and inflammation. The GPR132 Polyclonal Antibody offers researchers a reliable tool for investigating the role of GPR132 in health and disease.
Antibody Name:
GPR132 Antibody
Antibody SKU:
PACO04015
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IHC, IF
Recommended Dilutions:
WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000
Species Reactivity:
Human
Immunogen:
synthesized peptide derived from the C-terminal region of human GPR132.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
GPR132; G2A; Probable G-protein coupled receptor 132; G2 accumulation protein
UniProt Protein Function:
May be a receptor for oxidized free fatty acids derived from linoleic and arachidonic acids such as 9-hydroxyoctadecadienoic acid (9-HODE). Activates a G alpha protein, most likely G alpha(q). May be involved in apoptosis. Functions at the G2/M checkpoint to delay mitosis. May function as a sensor that monitors the oxidative states and mediates appropriate cellular responses such as secretion of paracrine signals and attenuation of proliferation. May mediate ths accumulation of intracellular inositol phosphates at acidic pH through proton-sensing activity.
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein was reported to be a receptor for lysophosphatidylcholine action, but PubMedID: 15653487 retracts this finding and instead suggests this protein to be an effector of lysophosphatidylcholine action. This protein may have proton-sensing activity and may be a receptor for oxidized free fatty acids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
