The GPR107 Polyclonal Antibody (PAC061009) is a valuable tool for researchers studying G protein-coupled receptor 107 (GPR107), a protein involved in various physiological processes, including cell signaling and regulation of immune responses. This antibody, produced in rabbits, exhibits high reactivity with human samples and is ideal for use in Western blot applications to detect GPR107 protein levels.GPR107 is known to play a role in modulating the immune system, making it a promising target for studies related to immunology and cancer research. By utilizing the GPR107 Polyclonal Antibody, researchers can effectively detect and analyze GPR107 expression in different cell types, providing valuable insights into its function and potential therapeutic implications in diseases such as cancer and autoimmune disorders.
Given the importance of GPR107 in immune regulation and cellular signaling pathways, understanding its mechanisms of action is crucial for developing targeted therapeutics and strategies for treating various immune-related conditions. The GPR107 Polyclonal Antibody offers a reliable tool for investigating the role of GPR107 in physiological and pathological processes, contributing to advancements in biomedical research and drug discovery efforts.
IHC image of PACO61009 diluted at 1:400 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Immunofluorescence staining of U251 cells with PACO61009 at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Involved in Golgi-to-ER retrograde transport. Functions as a host factor required for infection by Pseudomonas aeruginosa exotoxin A and Campylobacter jejuni CDT toxins.
Synonyms:
Protein GPR107 (Lung seven transmembrane receptor 1), GPR107, KIAA1624 LUSTR1
UniProt Protein Function:
GPR107: Belongs to the LU7TM family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-passChromosomal Location of Human Ortholog: 9q34.11Cellular Component: Golgi apparatus; integral to membrane
