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GNMT Monoclonal Antibody [PAT3F6AT] (CPAB0206)

SKU:
CPAB0206
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG2a
Clone:
PAT3F6AT
Applications:
WB
ELISA
FC
€149
Frequently bought together:

Description

system_update_alt Datasheet

GNMT Monoclonal Antibody [PAT3F6AT] (CPAB0206)

The GNMT Polyclonal Antibody (CPAB0206) is a valuable tool for researchers studying the glycine N-methyltransferase (GNMT) protein. This antibody, produced in rabbits, exhibits high reactivity with human samples and is suitable for use in Western blot applications. By binding to GNMT, this antibody enables the detection and analysis of the protein in various cell types, making it ideal for investigations in liver metabolism, cancer research, and other related fields.GNMT is a key enzyme involved in regulating the balance of one-carbon metabolism and methionine metabolism, playing a crucial role in maintaining cellular homeostasis.

Dysregulation of GNMT has been linked to various diseases, including liver cancer, non-alcoholic fatty liver disease, and metabolic disorders. Therefore, understanding the function and expression of GNMT is essential for developing therapeutic strategies targeting these conditions.Overall, the GNMT Polyclonal Antibody provides researchers with a reliable tool for exploring the role of GNMT in health and disease, offering valuable insights into potential therapeutic interventions for a range of metabolic disorders and cancer types.

Product Name:GNMT Antibody
Product Sku:CPAB0206
Size:5μg
Host Species:Mouse
Immunogen:Anti-human GNMT mAb, is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with recombinant human GNMT amino acids 44-51 purified from Ecoli.
Clone:PAT3F6AT.
Reactivity:Human
Applications:Western Blot, ELISA, Flow Cytometry
Purification Method:GNMT antibody was purified from mouse ascitic fluids by protein-A affinity chromatography.
Isotype:IgG2a
Background:GNMT is an enzyme that catalyzes the conversion of S-adenosyl-L-methionine with glycine to S-adenosyl-L-homocysteine and sarcosine. GNMT is located in the cytoplasm and acts as a homotetramer. Defects in the GNMT gene causes of GNMT deficiency (hypermethioninemia). GNMT affects DNA methylation by regulating the ratio of S-adenosylmethionine to S-adenosylhomocystine and is involved in the detoxification pathway in liver cells. GNMT expression is diminished in human hepatocellular carcinoma (HCC). GNMT catalyzes the methylation of glycine by using s- adenosylmethionine (adomet) to form n-methylglycine (sarcosine) with the concomitant production of s-adenosylhomocysteine (adohcy). GNMT plays an essential role in the regulation of tissue concentration of adomet and of metabolism of methionine.
Synonyms:Glycine N-methyltransferase, GNMT.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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