The GLS Antibody (PAC034000) is a polyclonal antibody designed for research involving GLS, a key enzyme in the glutaminolysis pathway that plays a critical role in cancer metabolism. This antibody, raised in rabbits, is highly reactive with human samples and is validated for use in various applications, including Western blot, immunohistochemistry, and flow cytometry. It specifically binds to the GLS protein, enabling detection and analysis in different cellular contexts.GLS is a crucial enzyme involved in the conversion of glutamine to glutamate, a process that fuels cancer cell growth and survival. Its overexpression has been implicated in various cancer types, making it a promising target for therapeutic intervention.
By studying the activity of GLS, researchers can gain insights into cancer metabolism and potentially develop novel strategies for cancer treatment.Overall, the GLS Antibody is an essential tool for researchers studying cancer metabolism and the role of glutaminolysis in cancer progression. Its specificity and reliability make it ideal for investigating GLS expression and activity in both normal and cancerous tissues, advancing our understanding of the molecular mechanisms driving cancer development and progression.
Antibody Name:
glsA1 Antibody (PACO34000)
Antibody SKU:
PACO34000
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:1000-1:5000
Species Reactivity:
Escherichia coli
Immunogen:
Recombinant Escherichia coli Glutaminase 1 protein (1-310AA)
Western blot. All lanes: glsA1 antibody at 2µg/ml + DH5a whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 33 kDa. Observed band size: 33 kDa.
Synonyms:
Glutaminase 1 (EC 3.5.1.2), glsA1, ybaS
UniProt Protein Function:
UniProt Protein Details:
NCBI Summary:
Two glutaminases have been purified and biochemically characterized from Escherichia coli B. ybaS might contribute to acid resistance (Brown, 2008). [More information is available at EcoGene: EG13247]. YbaS is a glutaminase that is highly selective for L-glutamine. [More information is available at EcoCyc: G6261].
