The Gemin5 Polyclonal Antibody (CAB17125) is a powerful tool for researchers studying Gemin5, a key player in RNA metabolism and processing. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blotting applications. By specifically binding to the Gemin5 protein, this antibody allows for precise detection and analysis in a variety of cell types, making it an ideal choice for investigations in RNA biology, gene regulation, and developmental biology.Gemin5, a crucial component of the spliceosomal complex, plays a vital role in RNA splicing and transport, as well as in the regulation of gene expression.
Its importance in these processes makes it a valuable target for research in fields such as molecular biology, genetics, and neurobiology. By understanding the function of Gemin5, researchers can gain insights into various diseases and disorders, including neurodegenerative diseases, genetic disorders, and developmental abnormalities. The Gemin5 Polyclonal Antibody provides researchers with a valuable tool to further explore the role of Gemin5 in these contexts and develop new therapeutic strategies.
Product Name:
GEMIN5 Rabbit Polyclonal Antibody
SKU:
CAB17125
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 750-950 of human GEMIN5 (NP_056280.2).
cytoplasm, cytosol, Gemini of coiled bodies, nuclear body, nucleoplasm, nucleus, SMN-Sm protein complex
Calculated MW:
169kDa
Observed MW:
180kDa
This gene encodes a WD repeat protein that is a component of the survival of motor neurons (SMN) complex. The SMN complex plays a critical role in mRNA splicing through the assembly of spliceosomal small nuclear ribonucleoproteins (snRNPs), and may also mediate the assembly and transport of other classes of ribonucleoproteins. The encoded protein is the snRNA-binding component of the SMN complex. Dysregulation of this gene may play a role in alternative mRNA splicing and tumor cell motility. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Purification Method:
Affinity purification
Gene ID:
25929
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from HeLa cells, using GEMIN5 Rabbit pAb (CAB17125) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
