Fuca1 Antibody (PACO53890)
- SKU:
- PACO53890
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
Fuca1 Antibody (PACO53890)
The FUCA1 Polyclonal Antibody (PAC053890) is a valuable tool for researchers studying FUCA1, an enzyme involved in lysosomal degradation of fucose-containing glycoproteins. This antibody is produced in rabbits and is highly specific for human samples, making it ideal for a variety of research applications, including Western blotting.FUCA1 plays a critical role in the breakdown of fucose-containing molecules, making it essential for proper cellular function. Dysregulation of FUCA1 has been implicated in a variety of diseases, including cancer and lysosomal storage disorders.
By using the FUCA1 Polyclonal Antibody, researchers can study the expression and localization of FUCA1 in different cell types, providing valuable insights into its function and potential therapeutic applications.This antibody is an essential tool for researchers interested in understanding the role of FUCA1 in health and disease, and its high specificity and sensitivity make it a reliable choice for studying this important enzyme.
| Antibody Name: | Fuca1 Antibody (PACO53890) |
| Antibody SKU: | PACO53890 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000 |
| Species Reactivity: | Mouse, Rat |
| Immunogen: | Recombinant Mouse Tissue alpha-L-fucosidase protein (18-452AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: Rat kideny tissue. All lanes: Fuca1 antibody at 3.4µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 53 kDa. Observed band size: 53 kDa. |
| Background: | Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. |
| Synonyms: | Tissue alpha-L-fucosidase (EC 3.2.1.51) (Alpha-L-fucosidase I) (Alpha-L-fucoside fucohydrolase 1) (Alpha-L-fucosidase 1), Fuca1, Fuca |
| UniProt Protein Function: | FUCA1: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N- acetylglucosamine of the carbohydrate moieties of glycoproteins. Defects in FUCA1 are the cause of fucosidosis (FUCA1D). FUCA1D is an autosomal recessive lysosomal storage disease characterized by accumulation of fucose-containing glycolipids and glycoproteins in various tissues. Clinical signs include facial dysmorphism, dysostosis multiplex, moderate hepatomegaly, severe intellectual deficit, deafness, and according to age, angiokeratomas. Belongs to the glycosyl hydrolase 29 family. |
| UniProt Protein Details: | Protein type:EC 3.2.1.51; Glycan Metabolism - other glycan degradation; Hydrolase Chromosomal Location of Human Ortholog: 4 D3|4 68.01 cM Cellular Component: lysosome Molecular Function:alpha-L-fucosidase activity; carbohydrate binding; fucosidase activity; hydrolase activity; hydrolase activity, acting on glycosyl bonds Biological Process: carbohydrate metabolic process; fucose metabolic process; glycoside catabolic process; metabolic process |
| UniProt Code: | Q99LJ1 |
| NCBI GenInfo Identifier: | 169808427 |
| NCBI Gene ID: | 71665 |
| NCBI Accession: | NP_077205.3 |
| UniProt Secondary Accession: | Q99LJ1,Q3UAH8, Q8BN13, Q9DD22, B1AV51, |
| UniProt Related Accession: | Q99LJ1 |
| Molecular Weight: | 52,281 Da |
| NCBI Full Name: | tissue alpha-L-fucosidase |
| NCBI Synonym Full Names: | fucosidase, alpha-L- 1, tissue |
| NCBI Official Symbol: | Fuca1Â Â |
| NCBI Official Synonym Symbols: | Afuc; Fuca; 0610006A03Rik; 9530055J05Rik  |
| NCBI Protein Information: | tissue alpha-L-fucosidase |
| UniProt Protein Name: | Tissue alpha-L-fucosidase |
| UniProt Synonym Protein Names: | Alpha-L-fucosidase I; Alpha-L-fucoside fucohydrolase 1; Alpha-L-fucosidase 1 |
| Protein Family: | Tissue alpha-L-fucosidase |
| UniProt Gene Name: | Fuca1Â Â |
| ELISA Kits |
| Mouse Tissue alpha -L-Fucosidase / FUCA1 ELISA Kit |
| Mouse Tissue alpha-L-fucosidase (Fuca1) ELISA Kit |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
Related Products
Human Tissue alpha -L-Fucosidase / FUCA1 ELISA Kit
Human Tissue alpha-L-fucosidase (FUCA1) ELISA Kit (HUEB0863)
Mouse Tissue alpha -L-Fucosidase / FUCA1 ELISA Kit
Human Fucosidase Alpha L1, Tissue (FUCa1) ELISA Kit
Mouse Tissue alpha-L-fucosidase (Fuca1) ELISA Kit (MOEB0605)
