FLT3 Rabbit Polyclonal Antibody (CAB7897)
- SKU:
- CAB7897
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Frequently bought together:
Description
Product Name: | FLT3 Rabbit Polyclonal Antibody |
SKU: | CAB7897 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 27-270 of human FLT3 (NP_004110.2). |
Sequence: | NQDL PVIK CVLI NHKN NDSS VGKS SSYP MVSE SPED LGCA LRPQ SSGT VYEA AAVE VDVS ASIT LQVL VDAP GNIS CLWV FKHS SLNC QPHF DLQN RGVV SMVI LKMT ETQA GEYL LFIQ SEAT NYTI LFTV SIRN TLLY TLRR PYFR KMEN QDAL VCIS ESVP EPIV EWVL CDSQ GESC KEES PAVV KKEE KVLH ELFG TDIR CCAR NELG RECT RLFT IDLN QTPQ TTLP QLFL KVGE PLWI |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | FLK2; STK1; CD135; FLK-2; FLT3 |
Positive Sample: | Mouse liver |
Conjugate: | Unconjugated |
Cellular Localization: | Endoplasmic reticulum lumen, Membrane, Single-pass type I membrane protein. |
Calculated MW: | 113kDa |
Observed MW: | 160kDa |
This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.
Purification Method: | Affinity purification |
Gene ID: | 2322 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |