The FBXO40 Polyclonal Antibody (PAC041778) is a valuable tool for researchers investigating the function of FBXO40, a protein involved in cellular signaling and protein degradation pathways. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the FBXO40 protein, this antibody enables the accurate detection and analysis of FBXO40 expression in different cell types, making it ideal for studies in cell biology and cancer research.The FBXO40 protein is part of the SCF (SKP1-cullin-F-box) complex, which plays a crucial role in targeting specific proteins for degradation through the ubiquitin-proteasome system.
Dysregulation of FBXO40 has been implicated in a variety of diseases, including cancer and neurodegenerative disorders. By studying the function of FBXO40, researchers can gain insights into the molecular mechanisms underlying these conditions and identify potential therapeutic targets for intervention.In summary, the FBXO40 Polyclonal Antibody is a valuable research tool for investigating the function of FBXO40 in cellular processes and disease pathogenesis. Its high specificity and sensitivity make it a reliable choice for researchers looking to explore the role of FBXO40 in various biological contexts.
Antibody Name:
FBXO40 Antibody (PACO41778)
Antibody SKU:
PACO41778
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human F-box only protein 40 protein (201-500AA)
Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using PACO41778 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human heart tissue using PACO41778 at dilution of 1:100.
Background:
Probable substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that may function in myogenesis.
Synonyms:
F-box only protein 40 (Muscle disease-related protein), FBXO40, FBX40 KIAA1195
UniProt Protein Function:
FBXO40: Probable substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that may function in myogenesis.Protein type: Unknown functionChromosomal Location of Human Ortholog: 3q13.33Cellular Component: cytoplasmMolecular Function: zinc ion bindingBiological Process: muscle cell differentiation; protein ubiquitination
UniProt Protein Details:
NCBI Summary:
Members of the F-box protein family, such as FBXO40, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
