fbpA Antibody (PACO33924)
- SKU:
- PACO33924
- Product Type:
- Antibody
- Reactivity:
- Bacteria
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
fbpA Antibody (PACO33924)
The FBPA Polyclonal Antibody (PACO33924) is a powerful tool for researchers studying FBPA, a key enzyme in the glycolysis pathway that plays a vital role in cellular energy production. This antibody, produced in rabbits, exhibits high reactivity specifically with human samples and has been rigorously validated for use in Western blot applications. By binding to the FBPA protein, researchers can accurately detect and analyze FBPA levels in a variety of cell types, making it an essential component in studies related to metabolism, cancer, and other diseases.
FBPA, also known as fructose-1,6-bisphosphate aldolase, is involved in catalyzing a crucial step in glycolysis, making it essential for producing energy within cells. Dysregulation of FBPA has been linked to metabolic disorders, cancer progression, and other pathological conditions, making it a promising target for drug development and therapeutic interventions. Understanding the role of FBPA in cellular metabolism is key to elucidating its impact on disease progression and identifying potential treatment strategies.
| Antibody Name: | fbpA Antibody (PACO33924) |
| Antibody SKU: | PACO33924 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000 |
| Species Reactivity: | Mycobacterium tuberculosis |
| Immunogen: | Recombinant Mycobacterium tuberculosis Diacylglycerol acyltransferase/mycolyltransferase Ag85A protein (53-331AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot All lanes: Antigen 85-A antibody at 2µg/ml Lane 1: Recombinant Mycobacterium tuberculosis Antigen 85-A protein 1µg Lane 2: Recombinant Mycobacterium tuberculosis Antigen 85-A protein 10µg Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 36 kDa Observed band size: 36 kDa . |
| Background: | Proteins of the antigen 85 complex are responsible for the high affinity of mycobacteria to fibronectin. Possesses a mycolyltransferase activity required for the biogenesis of trehalose dimycolate (cord factor), a dominant structure necessary for maintaining cell wall integrity. |
| Synonyms: | Diacylglycerol acyltransferase/mycolyltransferase Ag85A (DGAT) (EC 2.3.1.122) (EC 2.3.1.20) (Acyl-CoA:diacylglycerol acyltransferase) (Antigen 85 complex A) (85A) (Ag85A) (Fibronectin-binding protein A) (Fbps A), fbpA, mpt44 |
| UniProt Protein Function: | The antigen 85 proteins (FbpA, FbpB, FbpC) are responsible for the high affinity of mycobacteria for fibronectin, a large adhesive glycoprotein, which facilitates the attachment of M.tuberculosis to murine alveolar macrophages (AMs). They also help to maintain the integrity of the cell wall by catalyzing the transfer of mycolic acids to cell wall arabinogalactan, and through the synthesis of alpha,alpha-trehalose dimycolate (TDM, cord factor). They catalyze the transfer of a mycoloyl residue from one molecule of alpha,alpha-trehalose monomycolate (TMM) to another TMM, leading to the formation of TDM. FbpA mediates triacylglycerol (TAG) formation with long-chain acyl-CoA as the acyl donor and 1,2-dipalmitoyl-sn-glycerol (1,2-dipalmitin) as the acyl acceptor. It has a preference for C26:0-CoA over C18:1-CoA. |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | P9WQP3 |
| NCBI GenInfo Identifier: | 15610940 |
| NCBI Gene ID: | 886132 |
| NCBI Accession: | NP_218321.1 |
| UniProt Secondary Accession: | P9WQP3,P0A4V2, P17944, P17996, D6MJP3, F2GDG3 |
| UniProt Related Accession: | P9WQP3 |
| Molecular Weight: | 35,686 Da |
| NCBI Full Name: | diacylglycerol acyltransferase/mycolyltransferase Ag85A |
| NCBI Synonym Full Names: | |
| NCBI Official Symbol: | fbpAÂ Â |
| NCBI Official Synonym Symbols: | 85A; mpt44Â Â |
| NCBI Protein Information: | diacylglycerol acyltransferase/mycolyltransferase Ag85A |
| UniProt Protein Name: | Diacylglycerol acyltransferase/mycolyltransferase Ag85A |
| UniProt Synonym Protein Names: | Acyl-CoA:diacylglycerol acyltransferase; Antigen 85 complex A; 85A; Ag85A; Fibronectin-binding protein A; Fbps A |
| Protein Family: | Major ferric iron-binding protein |
| UniProt Gene Name: | fbpAÂ Â |
| UniProt Entry Name: | A85A_MYCTU |
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