The Exportin-T Polyclonal Antibody (CAB12043) is a valuable tool for researchers studying Exportin-T, a protein involved in nuclear export processes within the cell. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By targeting Exportin-T, researchers can analyze its role in nucleocytoplasmic transport and gene expression regulation, particularly in cancer and developmental biology studies.Exportin-T is a key player in transporting RNA molecules and proteins out of the nucleus, making it essential for cellular function and gene expression control.
Dysregulation of Exportin-T has been implicated in various diseases, including cancer and neurodevelopmental disorders, highlighting its importance as a therapeutic target. By investigating the function of Exportin-T, researchers can uncover new insights into cellular processes and potentially identify novel treatment strategies for diseases linked to nuclear export dysfunction.
Product Name:
XPOT Rabbit Polyclonal Antibody
SKU:
CAB12043
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human XPOT (NP_009166.2).
B cells,Mouse brain,Mouse kidney,Mouse liver,Rat kidney
Conjugate:
Unconjugated
Cellular Localization:
Cytoplasm, Nucleus.
Calculated MW:
110kDa
Observed MW:
100kDa
This gene encodes a protein belonging to the RAN-GTPase exportin family that mediates export of tRNA from the nucleus to the cytoplasm. Translocation of tRNA to the cytoplasm occurs once exportin has bound both tRNA and GTP-bound RAN.
Purification Method:
Affinity purification
Gene ID:
11260
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using XPOT Rabbit pAb (CAB12043) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.