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Everything You Need to Know About Preeclampsia: A Guide


Preeclampsia is a serious condition that can develop during pregnancy. It is marked by high blood pressure and the presence of protein in the urine and can cause serious problems for both mother and baby if it is not treated. A recent study found that preeclampsia is associated with an increased risk of heart disease in later life. It can lead to high blood pressure and diabetes, which both increase the risk of cardiovascular disease. It may also cause damage to arteries and reduce blood flow to the placenta (leading to low birth weight). Therefore, it’s essential that pregnant women should be screened for preeclampsia at their first prenatal visit so that treatment can begin early if necessary.

Luckily, research into the symptoms and treatments for preeclampsia is progressing. In a recent study by Nikolov et al., in the Annals of Clinical and Analytical Medicine, it was shown that Collagen type III to type I propeptides ratio is а better indicator of early-onset preeclampsia than a single propeptide. This group used our Assay Genie PIIINP, PICP and PINP ELISA kits to determine the usage of these molecules as more useful biomarkers of preeclampsia.

In this article, we will discuss what preeclampsia is, what causes it, how to treat it and the Assay Genie PIIINP, PICP and PINP ELISA kits used to determine the usage of these molecules as biomarkers of preeclampsia.

What is Preeclampsia?

Preeclampsia can occur during pregnancy or after giving birth and is a condition in which the mother has high blood pressure and proteinuria (excess amounts of protein in her urine). Preeclampsia usually begins after 20 weeks gestation but may develop earlier if there are underlying conditions such as gestational diabetes mellitus (GDM), preexisting hypertension (high blood pressure before becoming pregnant), obesity, kidney disease, autoimmune disorders like lupus erythematosus or antiphospholipid syndrome use of certain medications including antihypertensives angiotensin converting enzyme inhibitors/angiotensin receptor blockers, anesthetic agents or immunosuppressants thiazides beta-blockers.

Preeclampsia Complications

The maternal complications associated with preeclampsia can include:

- Severe headache

- Blurred vision or temporary blindness

- Nausea and vomiting

- Upper abdominal pain, most often in the right side

- Rapid weight gain (more than five pounds in a week) due to fluid retention

- Persistent swelling of the face, hands, feet, or abdomen

- Shortness of breath

- Decreased urine output or excessive foaming in urine

 


The baby's complications can include:

- Low birth weight

- Premature birth

- Death of the baby

How is preeclampsia diagnosed and treated?

Preeclampsia is diagnosed by measuring blood pressure and urine protein levels. Preeclampsia can be mild, moderate, or severe. Treatment depends on the severity of the condition. If preeclampsia is mild, treatment may only include bed rest and close monitoring. If preeclampsia is more severe, delivery of the baby may be necessary. In some cases, medication such as magnesium sulfate may be given to prevent seizures (eclampsia). The earlier it is detected and treated, the better the outcome for both mother and baby.

Preeclampsia vs Eclampsia

Preeclampsia differs from eclampsia in that it is a condition that can develop during pregnancy, while eclampsia is a condition that develops after delivery. Preeclampsia is marked by high blood pressure and the presence of protein in the urine, while eclampsia is characterized by seizures.

Preeclampsia Research

A recent study found that preeclampsia is associated with an increased risk of heart disease in later life. It can lead to high blood pressure and diabetes, which both increase the risk of cardiovascular disease. It may also cause damage to arteries and reduce blood flow to the placenta (leading to low birth weight). Pregnant women should be screened for preeclampsia at their first prenatal visit so that treatment can begin early if necessary.

Preeclampsia Prevention

There is no known way to prevent preeclampsia, but early diagnosis and treatment are important. Pregnant women should be screened at their first prenatal visit so that treatment can begin early if necessary. Preeclampsia can also be detected with regular ultrasounds and blood pressure checks. If you have any of the risk factors for preeclampsia, be sure to let your doctor know.

Magnesium Sulfate for Preeclampsia

Magnesium sulfate is a medication that can be used to prevent seizures in women with preeclampsia. Magnesium sulfate works by slowing the electrical activity of the brain. It is important to note that magnesium sulfate does not cure preeclampsia, but it can help to prevent seizures. Magnesium sulfate is given as an injection or infusion into a vein.

Gestational Hypertension vs Preeclampsia

Gestational hypertension is a condition in which blood pressure rises to above 140/90 mmHg during pregnancy. Preeclampsia is a more severe form of gestational hypertension that can develop complications such as seizures or kidney failure. Pregnant women with preeclampsia require urgent treatment to prevent these life-threatening complications from developing. Preeclampsia affects about five percent of all pregnancies, but it can be prevented by early diagnosis and treatment.

Preeclampsia Blood Pressure Range

The blood pressure range for preeclampsia is 140/90 mmHg or higher. Preeclampsia can be mild, moderate, or severe, so not all pregnant women with a blood pressure above 140/90 mmHg will develop the condition. However, it is important to get any increase in blood pressure checked out by a doctor as soon as possible.

When does Preeclampsia Start?

Preeclampsia can start at any time during pregnancy, but it is most commonly diagnosed in the third trimester. Preeclampsia typically starts after 20 weeks of gestation and affects about five percent of all pregnancies. Preeclampsia can be mild, moderate, or severe, so not all pregnant women with a blood pressure above 140/90 mmHg will develop the condition. However, it is important to get any increase in blood pressure checked out by a doctor as soon as possible.

Superimposed Preeclampsia

Superimposed preeclampsia occurs when a pregnant woman has high blood pressure before 20 weeks of gestation and then develops proteinuria or other symptoms of preeclampsia after 20 weeks. Preeclampsia is more common in women who were hypertensive before pregnancy, so it is important to get your blood pressure checked at least once per year if you are pregnant or planning on becoming pregnant. Preeclampsia can be mild, moderate, or severe, so not all pregnant women with a blood pressure above 140/90 mmHg will develop the condition. However, it is important to get any increase in blood pressure checked out by a doctor as soon as possible.

Our Cited Preclampsia Related Kits:

9th Feb 2022 Colm Ryan PhD

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