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ERI1 Antibody (PACO22811)

SKU:
PACO22811
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
$503
Frequently bought together:

Description

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ERI1 Antibody (PACO22811)

The ERI1 Antibody (PAC022811) is a polyclonal antibody designed for research involving the ERI1 protein, a key player in RNA processing and degradation. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By detecting and binding to the ERI1 protein, researchers can study its function and role in various cellular processes, making it an essential tool for studies in RNA biology and gene regulation.ERI1, also known as ERI1 exoribonuclease 1, is involved in mRNA degradation and quality control mechanisms, making it critical for maintaining cellular homeostasis.

Understanding the function of ERI1 is important for unraveling the complexities of RNA metabolism and its impact on gene expression. Research into ERI1 can provide insights into diseases linked to RNA dysregulation, such as cancer, neurodegenerative disorders, and viral infections, paving the way for potential therapeutic interventions targeting these pathways.

Antibody Name:ERI1 Antibody (PACO22811)
Antibody SKU:PACO22811
Size:100ul
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:Human
Immunogen:Synthesized peptide derived from internal of human ERI1.
Form:Liquid
Storage Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageWestern blot analysis of extracts from COLO205 cells, using ERI1 antibody.
Background:RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2' and 3'-hydroxyl groups at the last nucleotide of the histone 3'-end is required for efficient degradation of RNA substrates. Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Requires for binding the 5'-ACCCA-3' sequence present in stem-loop structure. Able to bind other mRNAs. Required for 5.8S rRNA 3'-end processing. Also binds to 5.8s ribosomal RNA. Binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs.
Synonyms:3-5 exoribonuclease 1; 3-5 exonuclease ERI1; Eri-1 homolog; Histone mRNA 3-end-specific exoribonuclease; Histone mRNA 3-exonuclease 1
UniProt Protein Function:THEX1: RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2' and 3'-hydroxyl groups at the last nucleotide of the histone 3'-end is required for efficient degradation of RNA substrates. Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Requires for binding the 5'-ACCCA-3' sequence present in stem-loop structure. Able to bind other mRNAs. Required for 5.8S rRNA 3'-end processing. Also binds to 5.8s ribosomal RNA. Binds with high affinity to the stem-loop structure of replication- dependent histone pre-mRNAs. Identified in a histone pre-mRNA complex, at least composed of ERI1, LSM11, SLBP, SNRPB, SYNCRIP and YBX1. Interacts in a cooperative manner with SLBP to the mature 3'-end of histone mRNAs. Binds to 40S and 60S ribosomal subunits and to 80S assembled ribosomes. Found in a ternary complex with SLBP and the stem-loop structure of the 3'-end of histone mRNAs. Although it can bind simultaneously with SLBP to the 3'-end of histone mRNA, the presence of SLBP prevents the exonuclease activity.Protein type: EC 3.1.-.-; Hydrolase; NucleolusChromosomal Location of Human Ortholog: 8p23.1Cellular Component: cytoplasm; nucleolus; nucleusMolecular Function: 3'-5' exonuclease activity; ribosome binding; rRNA bindingBiological Process: exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); rRNA 3'-end processing
UniProt Protein Details:
NCBI Summary:
UniProt Code:Q8IV48
NCBI GenInfo Identifier:45476938
NCBI Gene ID:90459
NCBI Accession:Q8IV48.3
UniProt Secondary Accession:Q8IV48,Q9NSX3, A8K4U7
UniProt Related Accession:Q8IV48
Molecular Weight:40,064 Da
NCBI Full Name:3'-5' exoribonuclease 1
NCBI Synonym Full Names:exoribonuclease 1
NCBI Official Symbol:ERI1  
NCBI Official Synonym Symbols:HEXO; THEX1; 3'HEXO  
NCBI Protein Information:3'-5' exoribonuclease 1
UniProt Protein Name:3'-5' exoribonuclease 1
UniProt Synonym Protein Names:3'-5' exonuclease ERI1; Eri-1 homolog; Histone mRNA 3'-end-specific exoribonuclease; Histone mRNA 3'-exonuclease 1; Protein 3'hExo; HEXO
Protein Family:ERI1 exoribonuclease
UniProt Gene Name:ERI1  
UniProt Entry Name:ERI1_HUMAN
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