The EPS8L2 Polyclonal Antibody (PAC042186) is a valuable tool for researchers studying EPS8L2, a protein involved in various cellular processes, including cell proliferation, migration, and differentiation. This antibody, raised in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding to the EPS8L2 protein, this antibody enables researchers to detect and analyze EPS8L2 expression in a variety of cell types, making it ideal for studies in molecular biology and cancer research.EPS8L2, also known as epidermal growth factor receptor kinase substrate 8-like protein 2, plays a critical role in modulating cell signaling pathways that regulate cell growth and survival.
Its involvement in these processes makes it a promising target for research into cancer and other diseases characterized by aberrant cell proliferation. Understanding the function of EPS8L2 is essential for developing targeted therapies that can disrupt or enhance its activity in the context of various disease states.Overall, the EPS8L2 Polyclonal Antibody (PAC042186) is a reliable tool for researchers investigating the role of EPS8L2 in cellular processes and disease pathology, providing valuable insights that may lead to the development of novel therapeutic interventions.
Antibody Name:
EPS8L2 Antibody (PACO42186)
Antibody SKU:
PACO42186
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Epidermal growth factor receptor kinase substrate 8-like protein 2 protein (201-500AA)
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO42186 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human skin tissue using PACO42186 at dilution of 1:100.
Background:
Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton.
Synonyms:
Epidermal growth factor receptor kinase substrate 8-like protein 2 (EPS8-like protein 2) (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-related protein 2), EPS8L2, EPS8R2
UniProt Protein Function:
EPS8L2: Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. Belongs to the EPS8 family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: GEFs; Actin-binding; GEFs, Rac/RhoChromosomal Location of Human Ortholog: 11p15.5Cellular Component: cytoplasm; plasma membrane; protein complex; vesicleMolecular Function: actin binding; Rac guanyl-nucleotide exchange factor activity; Rho guanyl-nucleotide exchange factor activityBiological Process: regulation of Rho protein signal transduction; Rho protein signal transduction
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the EPS8 gene family. The encoded protein, like other members of the family, is thought to link growth factor stimulation to actin organization, generating functional redundancy in the pathways that regulate actin cytoskeletal remodeling. [provided by RefSeq, Dec 2008]
