The ENPEP Polyclonal Antibody (CAB12339) is a valuable tool for researchers studying ENPEP, a cell surface enzyme involved in various physiological processes, including regulation of blood pressure and kidney function. This antibody, produced in rabbits, demonstrates high reactivity with human samples and is specially validated for use in Western blot applications. By binding to the ENPEP protein, this antibody enables precise detection and analysis in a variety of cell types, making it an essential component of studies in nephrology, cardiovascular research, and beyond.
ENPEP, also known as aminopeptidase A, is critical for the processing of peptides and plays a key role in maintaining fluid and electrolyte balance in the body. Dysregulation of ENPEP has been linked to hypertension, kidney disorders, and other cardiovascular diseases, making it a promising target for therapeutic interventions. Understanding the function of ENPEP is crucial for developing treatments that can effectively modulate its activity and potentially alleviate conditions associated with its dysfunction.
Product Name:
ENPEP Rabbit Polyclonal Antibody
SKU:
CAB12339
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 850-950 of human ENPEP (NP_001968.3).
The ENPEP gene encodes glutamyl aminopeptidase, a type II integral membrane protein with an extracellular zinc-binding domain. This protein can upregulate blood pressure by cleaving the N-terminal aspartate from angiotensin II, and can regulate blood vessel formation and enhance tumorigenesis in some tissues. Along with ANPEP and DPP4, ENPEP was found to be a candidate co-receptor for the coronavirus SARS-CoV-2, which causes COVID-19.
Purification Method:
Affinity purification
Gene ID:
2028
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using ENPEP Rabbit pAb (CAB12339) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
